Volume 8, Number 11—November 2002
THEME ISSUE
Tuberculosis Genotyping
Tuberculosis Genotyping Network, United States
Molecular Epidemiology of Multidrug-Resistant Tuberculosis, New York City, 1995–1997
Sonal S. Munsiff*†
, Trina Bassoff*, Beth Nivin*, Jiehui Li*, Anu Sharma*, Pablo Bifani‡, Barun Mathema‡, Jeffrey Driscoll§, and Barry N. Kreiswirth‡
, Trina Bassoff*, Beth Nivin*, Jiehui Li*, Anu Sharma*, Pablo Bifani‡, Barun Mathema‡, Jeffrey Driscoll§, and Barry N. Kreiswirth‡Table 2
Social and demographic characteristics of patients in predominantly multidrug-resistant tuberculosis clusters, New York City, 1995–1997
| Clustered strain (n=234) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Characteristics | W | W1 | H | AB | P | AU | C | P1 | Other | Unique RFLPa |
| No. of patients | 59 | 7 | 18 | 14 | 13 | 6 | 5 | 4 | 27 | 81 |
| No. of bands | 18 | 19 | 2 | 11 | 11 | 10 | 3 | 11 | 4–18 | 2–22 |
| Known epidemiologic links | ||||||||||
| Nosocomial | 6 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Community | 4 | 1 | 2 | 7 | 1 | 2 | 0 | 0 | 1 | 5 |
| Age (median, in yrs) | 41 | 41 | 37 | 42 | 43 | 40 | 37 | 37 | 41 | 42 |
| Male | 41 | 3 | 7 | 7 | 7 | 4 | 4 | 3 | 17 | 49 |
| Race/ethnicity | ||||||||||
| Asian | 2 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 16 |
| Hispanic | 18 | 2 | 10 | 1 | 3 | 1 | 3 | 2 | 9 | 24 |
| Black, non-Hispanic | 25 | 1 | 6 | 12 | 9 | 1 | 1 | 2 | 15 | 31 |
| White, non-Hispanic | 14 | 3 | 1 | 1 | 0 | 4 | 0 | 0 | 3 | 10 |
| U.S.-born | 46 | 4 | 15 | 13 | 10 | 5 | 3 | 3 | 21 | 42 |
| HIV positive | 42 | 1 | 14 | 10 | 4 | 4 | 3 | 1 | 17 | 29 |
| History of— | ||||||||||
| Homelessness | 6 | 0 | 1 | 8 | 3 | 0 | 2 | 0 | 2 | 5 |
| Alcohol abuse | 11 | 1 | 1 | 3 | 4 | 0 | 0 | 0 | 5 | 9 |
| Injection drug use | 9 | 0 | 2 | 6 | 0 | 1 | 0 | 1 | 5 | 8 |
| Prior tuberculosis treatment | 0 | 0 | 1 | 0 | 1 | 1 | 2 | 0 | 5 | 12 |
| Health-care worker | 4 | 3 | 1 | 0 | 1 | 0 | 1 | 0 | 2 | 2 |
| Borough of residence | ||||||||||
| Manhattan | 23 | 1 | 8 | 4 | 1 | 1 | 3 | 0 | 10 | 19 |
| Bronx | 17 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 2 | 8 |
| Brooklyn | 7 | 2 | 5 | 10 | 9 | 5 | 1 | 4 | 11 | 30 |
| Queens | 12 | 4 | 1 | 0 | 3 | 0 | 0 | 0 | 4 | 23 |
| Staten Island | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
aRFLP, restriction fragment length polymorphism.
