Volume 8, Number 11—November 2002
THEME ISSUE
Tuberculosis Genotyping

Tuberculosis Genotyping Network, United States

Molecular Typing of Mycobacterium tuberculosis Strains with a Common Two-Band IS6110 Pattern

Kerry H. Lok*, William H. Benjamin*, Michael E. Kimerling* , Virginia Pruitt†, Donna Mulcahy†, Nancy Robinson†, Nancy B. Keenan†, and Nancy E. Dunlap*

Author affiliations: *University of Alabama School of Medicine, Birmingham, Alabama, USA; †Alabama Department of Public Health, Montgomery, Alabama, USA;

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Table

Comparison of a common two-band IS6110 RFLP pattern with spoligotyping and VNTR^a

Spoligotyping		VNTR		Related to conventional outbreak
Octal (CDC designation)	No. of isolates	VNTR results (AL designation)	No. of isolates	Store	Bus	Homeless
777776777760601(0009)	55	6,3,2,4,2,3,2 (01)	22			2
		6,3,2,3,2,2,2 (02)	12		4	4
		6,3,2,4,2,3,3 (03)	8			2
		6,3,2,3,2,2,3 (04)	4			3
		6,3,2,2,2,2,2 (05)	3			3
		6,3,2,3,2,3,2 (06)	2
		6,3,2,3,2,3,3 (07)	2			1
		6,3,2,4,2,2,2 (08)	1
		6,2,2,3,2,2,2 (09)	1			1
037776777760601(0545)	14	6,3,2,3,2,4,2 (10)	14	14
777776777760771(0003)	12	6,3,2,2,2,1,2 (11)	7			5
		6,3,2,3,2,3,2.5 (12)	1
		6,3,2,2,2,1,3 (13)	1
		6,3,1,2,2,2,3 (14)	1			1
		6,3,2,3,2,2,2 (02)	1			1
		6,3,2,3,2,3,3 (07)	1
001776777760601(0550)	3	6,3,2,4,2,3,2 (01)	3
777776374360711(1445)	1	6,3,2,1,2,3,2.5 (15)	1			1
037766677760601(n/a)	1	6,3,2,3,2,4,2 (10)	1	1
Total	86		86	15	4	24

^aRFLP, restriction fragment length polymorphism; VNTR, variable number of tandem repeats, CDC, Centers for Disease Control and Prevention.

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