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Volume 8, Number 9—September 2002

Research

Molecular Characterization of Campylobacter jejuni Clones: A Basis for Epidemiologic Investigation

Kate E. Dingle*, Frances M. Colles*, Roisin Ure, Jaap A. Wagenaar‡, Birgitta Duim‡, Frederick J. Bolton, Andrew J. Fox§, David R.A. Wareing, and Martin C.J. Maiden*Comments to Author 
Author affiliations: *University of Oxford, Oxford, United Kingdom; †Public Health Laboratory, Royal Preston Hospital, Preston, United Kingdom; ‡Institute for Animal Science and Health, Lelystad, the Netherlands; §Public Health Laboratory, Withington Hospital, Manchester, United Kingdom;

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Table 2

Clonal complexes of Campylobacter jejuni isolates

Clonal complex Isolates
(n) STa of central genotype
No. of STs No. of cell-surface component variants
Cell-surface component variants (p<0.001) c
aspA glnA gltA glyA pgm tkt uncA HS serotypesb FlaA SVR Antigen combinations HS serotypes FlaA SVR
ST-21 271 2 1 1 3 2 1 5 98 11 8 24 1,2,4c,8,10 1,10
ST-45 93 4 7 10 4 1 7 1 48 31 17 44 6, 7, 9, 12, 15, 21, 27, 33, 38, 42, 45, 55, 57, 60 1, 2, 5, 8, 9, 12, 18, 27
ST-206 60 2 21 5 37 2 1 5 37 3 8 9 1,4c 1,11
ST-61 57 1 4 2 2 6 3 17 19 2 9 5 4c 6,13,14
ST-48 54 2 4 1 2 7 1 5 22 4 5 7 4c 1,4
ST-257 46 9 2 4 62 4 5 6 21 4 3 4 11 12
ST-353 29 7 17 5 2 10 3 6 24 9 8 14 3,11,37 2,11
ST-42 22 1 2 3 4 5 9 3 7 5 4 5 23,36,23/36 9
ST-403 20 10 27 16 19 10 5 7 12 5 6 7 35 35
ST-52 18 9 25 2 10 22 3 6 11 7 3 7 5,11 4
ST-177 17 17 2 8 5 8 2 4 17 5 13 7 - -
ST-354 13 8 10 2 2 11 12 6 4 5 7 8 53 1,20,33
ST-22 12 1 3 6 4 3 3 3 5 2 3 3 19 3
ST-433 11 2 59 4 38 17 12 35 11 6 3 9 1,53 -
ST-362 9 1 2 49 4 11 66 8 1 1 1 1 41 3
ST-179 10 1 6 7 2 40 32 3 9 2 2 3 - -
ST-49 6 3 1 5 17 11 11 6 2 2 2 2 18 11

aST, sequence type; HS, heat stable; SVR, short variable region; -, no antigen variants were associated that were statistically significant (p>0.001), but isolates were antigenically varied.
bHS 4 complex serotypes (4c) were counted as one serotype.
cAntigen variants that were significantly associated with a particular clonal complex by the chi-square test. Isolates containing other antigen variants were also found in each complex, as were isolates which were nontypable by HS serotyping.

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