Volume 9, Number 10—October 2003
Dispatch
Mycobacterium tuberculosis Beijing Genotype, the Netherlands
Martien W. Borgdorff*†
, Petra de Haas‡, Kristin Kremer‡, and Dick van Soolingen‡
, Petra de Haas‡, Kristin Kremer‡, and Dick van Soolingen‡Table
Risk factors for the Beijing genotype of Mycobacterium tuberculosis, the Netherlands, 1993–2000
| Risk factor | Beijing genotype | Total | (%) | Odds ratio |
|
|---|---|---|---|---|---|
| Crude | Adjustedb (95% confidence intervals) | ||||
| Y of diagnosis |
|||||
| 1993 |
23 |
669 |
3 |
1.09 |
1.08 (1.03 to 1.13) |
| 1994 |
41 |
941 |
4 |
(per year) |
|
| 1995 |
56 |
863 |
6 |
||
| 1996 |
50 |
946 |
5 |
||
| 1997 |
64 |
872 |
7 |
||
| 1998 |
58 |
804 |
7 |
||
| 1999 |
74 |
879 |
8 |
||
| 2000 |
49 |
855 |
6 |
||
| Sex |
|||||
| Male |
254 |
4,135 |
6 |
1 |
|
| Female |
161 |
2,694 |
6 |
0.97 |
|
| Age group |
|||||
| <25 |
120 |
1,522 |
8 |
1 |
1 |
| 25–34 |
123 |
1,925 |
6 |
0.80 |
0.69 (0.53 to 0.91) |
| 35–44 |
64 |
1,080 |
6 |
0.74 |
0.60 (0.43 to 0.83) |
| 45–54 |
23 |
614 |
4 |
0.45 |
0.36 (0.23 to 0.57) |
| 55–64 |
24 |
493 |
5 |
0.60 |
0.55 (0.35 to 0.88) |
| 65–74 |
40 |
517 |
8 |
0.98 |
0.78 (0.52 to 1.15) |
| 75+ |
21 |
678 |
3 |
0.37 |
0.30 (0.18 to 0.50) |
| Nationality |
|||||
| Netherlands |
160 |
2,825 |
6 |
1 |
1 |
| Europe (central and eastern) |
20 |
231 |
9 |
1.58 |
1.27 (0.77 to 2.09) |
| Turkey |
3 |
339 |
1 |
0.15 |
0.12 (0.04 to 0.38) |
| Morocco |
19 |
650 |
3 |
0.50 |
0.41 (0.25 to 0.68) |
| Somalia |
21 |
957 |
2 |
0.37 |
0.27 (0.17 to 0.44) |
| Africa (other) |
28 |
594 |
5 |
0.82 |
0.63 (0.41 to 0.96) |
| Asia |
140 |
786 |
18 |
3.61 |
3.01 (2.32 to 3.91) |
| Other |
19 |
345 |
6 |
0.97 |
0.86 (0.53 to 1.42) |
| Unknown |
5 |
102 |
5 |
0.86 |
0.73 (0.29 to 1.84) |
| RFLP clusteringa |
|||||
| No |
212 |
3,227 |
7 |
1 |
|
| Yes, first case |
57 |
1,052 |
5 |
0.81 |
|
| Yes, later case |
146 |
2,550 |
6 |
0.86 |
|
| Localization |
|||||
| Pulmonary |
268 |
4,064 |
7 |
1 |
|
| Extrapulmonary |
113 |
2,122 |
5 |
0.80 |
|
| Pulmonary and extrapulmonary |
34 |
643 |
5 |
0.79 |
|
| Residing in Netherlands |
|||||
| <6 months |
46 |
641 |
7 |
1 |
|
| 6–11 mo |
12 |
301 |
4 |
0.54 |
|
| 12–23 mo |
28 |
358 |
8 |
1.10 |
|
| 2–4 y |
53 |
767 |
7 |
0.96 |
|
| >5 y |
122 |
1,710 |
7 |
0.99 |
|
| Born in Netherlands |
117 |
2,437 |
5 |
0.65 |
|
| No information |
37 |
615 |
6 |
0.83 |
|
| Drug resistance |
|||||
| Susceptible |
332 |
5,910 |
6 |
1 |
|
| H only |
11 |
227 |
5 |
0.86 |
|
| S only |
34 |
358 |
9 |
1.76 |
|
| Other patterns |
26 |
221 |
12 |
2.24 |
|
| Multidrug-resistant |
9 |
53 |
17 |
3.44 |
|
| Unknown |
3 |
60 |
5 |
0.88 |
|
| Multidrug resistance |
|||||
| Yes |
9 |
53 |
17 |
3.21 |
2.64 (1.22 to 5.74) |
| No |
406 |
6,776 |
6 |
1 |
1 |
| HIV infection |
|||||
| Yes |
14 |
294 |
5 |
0.76 |
|
| No | 401 | 6,535 | 6 | 1 | |
aRFLP, restriction fragment length polymorphism.
bAdjusted for year of diagnosis, age, nationality, and multidrug resistance
