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Volume 9, Number 12—December 2003

Research

Mycobacterium abscessus and Children with Cystic Fibrosis

Isabelle Sermet-Gaudelus*, Muriel Le Bourgeois*, Catherine Pierre-Audigier*, Catherine Offredo*, Didier Guillemot†, Sophie Halley*, Chantal Akoua-Koffi*, Véronique Vincent†, Valérie Sivadon-Tardy‡, Agnès Ferroni*, Patrick Berche*, Pierre Scheinmann*, Gérard Lenoir*, and Jean-Louis Gaillard‡Comments to Author 
Author affiliations: *Hôpital Necker-Enfants Malades, Assistance Publique–Hôpitaux de Paris, Paris, France; †Institut Pasteur, Paris, France; ‡Hôpital Raymond Poincaré, Assistance Publique–Hôpitaux de Paris, Garches, France

Main Article

Table

Chronology of case-patients with Mycobacterium abcessus isolationa

Case no. Age (y)/sex Date of first isolation No. of pos. cultures/total AFB culturesb No. of pos. AFB smears/total AFB smearsb,c hsp65 genomovard Sputum
microbiologic resultse
1
2.5 / M
Jan 1996
37/48
19/31
(+++)
-6
Negative
2
13 / F
Feb 1996
2/14
0/9

T
Pseudomonas aeruginosa
3
15 / F
Apr 1996
3/41
0/21

-5a
P. aeruginosa
4
16 / M
Apr 1996
5/8
1/6
(+)
T
P. aeruginosa, Staphylococcus aureus, Aspergillus fumigatus
5
14 / F
May 1996
8/11
4/8
(++)
T
P. aeruginosa, S. aureus, A. fumigatus
6
10 / M
May 1996
4/25
0/12

T
P. aeruginosa, Alcaligenes xylosoxidans
7
9 / F
May 1996
8/8
4/7
(+++)
T
P. aeruginosa, Aspergillus fumigatus
8
2.5 / F
Nov 1997
4/6
2/5
(++)
-5a
Negative
9
7 / F
July 1998
2/24
0/7

-5a
S. aureus
10
17 / M
Sept 1998
3/9
0/6

T
S. aureus, Haemophilus influenzae, Stenotrophomonas maltophilia, A. fumigatus
11
8 / F
Sept 1998
3/12
0/4

T
P. aeruginosa, Staphylococcus aureus
12
18/F
July 1999
1/5
0/3

T
P. aeruginosa, A. fumigatus
13
9/M
Sept 1999
1/6
0/3

-6
S. aureus
14
16/M
Oct 1999
5/13
4/6
(+)
-5a
S. aureus, A. fumigatus
15 22/F Nov 1999 1/6 0/3 -6 P. aeruginosa, S. aureus

aAFB, acid-fast bacilli.
bSamples obtained from patients from January 1996 to December 2000; only samples obtained before the administration of antimycobacterial drugs are considered in treated patients.
cSymbols in parentheses: AFB density.
dSee Methods.
eOrganisms recovered from at least three sputum samples within the 12 months before the first isolation of M. abscessus.

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