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Volume 9, Number 12—December 2003

Dispatch

Scrub Typhus Reemergence in the Maldives

Michael D. Lewis*Comments to Author , Abdul Azeez Yousuf†, Kriangkrai Lerdthusnee*, Ahmed Razee‡, Kirkvitch Chandranoi*, and James W. Jones*
Author affiliations: *Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; †Ministry of Health, Malé, Republic of Maldives; ‡Indira Gandhi Memorial Hospital, Malé, Republic of Maldives

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Table 2

Testing results performed at the Armed Forces Research Institute of Medical Sciences

IIPa IFAb ELISAc
IgM (+)
14
15
14
IgG (+)
24
24
24
IgM (+) + IgG (+)
14
15
14
Total samples tested
28
28
28
PCRe and agarose gel electrophoresis positive results: 2 of 4

aIndirect immunoperoxidase test (positive if titer was ≥1:400) (15).
b Indirect immunofluorescent antibody test (positive if titer was ≥1:50) (15).
cEnzyme-linked immunosorbent assay (positive if PanBio units >11) (15).
dPositive immunoglobulin (Ig) M plus IgG results indicate active Orientia tsustugamushi infection. IgG without IgM indicates the persistence of IgG after a primary infection but with no active infection. The absence of both IgG and IgM indicates no exposure or a very early stage of infection (15).
ePolymerase chain reaction for O. tsustugamushi DNA (13).

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