Emerging Infectious Disease ISSN: 1080-6059

Human Neurobrucellosis with Intracerebral Granuloma Caused by a Marine Mammal Brucella spp.

Annette H. Sohn*

, Will S. Probert†, Carol A. Glaser*†, Nalin Gupta*, Andrew W. Bollen*, Jane D. Wong†, Elizabeth M. Grace*, and William C. McDonald*

Author affiliations: *University of California, San Francisco, San Francisco, California, USA; †California Department of Health Services, Richmond, California, USA

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Figure 1

Hematoxylin and eosin–stained sections from patient 1 (panels A, B) and patient 2 (panels C, D). Note the predominantly lymphohistocytic infiltrate forming large granulomas (A, original magnification 100x); well-formed giant cells (B, arrow, original magnification 200x); lymphohistiocytic infiltrates distorting brain parenchyma and forming vague granulomas (C, original magnification 40x); and the dense astrogliosis at the interface between granulomatous inflammation and surrounding brain parench

Figure 1. Hematoxylin and eosin–stained sections from patient 1 (panels A, B) and patient 2 (panels C, D). Note the predominantly lymphohistocytic infiltrate forming large granulomas (A, original magnification 100x); well-formed giant cells (B, arrow, original magnification 200x); lymphohistiocytic infiltrates distorting brain parenchyma and forming vague granulomas (C, original magnification 40x); and the dense astrogliosis at the interface between granulomatous inflammation and surrounding brain parenchyma (D, asterisk, original magnification 100x).

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