Emergence and Global Spread of a Dengue Serotype 3, Subtype III Virus
William B. Messer*, Duane J. Gubler†, Eva Harris‡, Kamalanayani Sivananthan§, and Aravinda M. de Silva*
Author affiliations: *University of North Carolina, Chapel Hill, North Carolina, USA; †Centers for Disease Control and Prevention, Fort Collins, Colorado, USA; ‡University of California, Berkeley, California, USA; §Medical Research Institute, Colombo, Sri Lanka.
Figure 1. Phylogenetic tree of established dengue virus 3 subtypes (23) and the relationship of Sri Lanka pre– and post–dengue hemorrhagic fever dengue virus 3 (DENV-3) isolates to the established subtypes. This tree is based on a 708-base segment, positions 437 to 1145, spanning pre-M/M and a portion of the E gene. Scale bar shows number of substitutions per bases weighted by Tamura-Nei algorithm. Horizontal distances are equivalent to the distances between isolates. Numbers at nodes indicate bootstrap support values for the branch of the tree inferred at that node. The origin of the viruses and sequences used are listed in Table 1. The amino acid substitutions conserved within each DENV-3 subtype are listed in Table 2. DHF, dengue hemorrhagic fever.
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