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Volume 9, Number 7—July 2003

Research

Emergence and Global Spread of a Dengue Serotype 3, Subtype III Virus

William B. Messer*, Duane J. Gubler†, Eva Harris‡, Kamalanayani Sivananthan§, and Aravinda M. de Silva*Comments to Author 
Author affiliations: *University of North Carolina, Chapel Hill, North Carolina, USA; †Centers for Disease Control and Prevention, Fort Collins, Colorado, USA; ‡University of California, Berkeley, California, USA; §Medical Research Institute, Colombo, Sri Lanka.

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Table 2

Amino acid substitutions conserved within each dengue virus 3 subtype for the isolates used to create the phylogenetic tree in Figure 1a

Subtype Name Position
31 55 57 128 135 148 188 234
Outgroup
56Philipp
I
H
T
L
I
L
D
I
I
73Indones

L

F



V
I
74Malaysi

L

F



V
I
78Indones

L

F



V
I
81Malaysi

L

F



V
I
83Philipp

L

F



V
I
85Indones

L

F



V
I
89Tahiti

L

F



V
I
92Fiji

L

F



V
II
62Thailan


A


W


II
73Thailan


A





II
86Thailan

L
A





II
87Thailan

L
A





III
85Mozamb1








III
85Mozamb2








III
85Mozamb3








III
84IndiaA








III
91Kenya








III
93Somolio








III
81SriLanA








III
83SriLan1








III
83SriLan2








III
83SriLan3








III
83SriLan4








III
84SriLan1








III
85SriLanA








III
85SriLan








III
89SriLan2








III
89SriLanA








III
89SriLan1








III
89SriLan3








III
90SriLan1








III
91SriLanA








III
93SriLan1








III
94SriLan1








III
97SriLan1








III
98SriLan1








III
86Samoa








IV
63PuertoR
T


F
L
M
E

IV
65Tahiti
T


F
L
M
E

IV 77PuertoR T F L M E

aReference strain 56Philipp is the highly passaged laboratory strain H87. Positions are numbered sequentially from the first position in the pre-M/M protein.

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