Volume 19, Number 1—January 2013
CME ACTIVITY - Research
Pneumocystis jirovecii Genotype Associated with Increased Death Rate of HIV-infected Patients with Pneumonia
Table 3
Multivariate analysis of risk factors for death attributed to PCP among 112 cases in 110 patients from 5 university hospitals, Lyon, France
Risk factor |
Death attributed to PCP
|
Adjusted RH (95% CI)† | p value | |
---|---|---|---|---|
Yes | No | |||
P. jirovecii PCR-SSCP type | ||||
7 |
4 | 5 | 4.2 (1.0–17.9) | 0.05 |
Others |
14
|
89
|
1.0 (Reference)
|
|
Mechanical ventilation at PCP diagnosis | ||||
Yes |
8 | 6 | 5.0 (1.8–13.5) | 0.002 |
No |
10
|
88
|
1.0 (Reference)
|
|
DHPS genotype | ||||
M3 |
5 | 15 | 1.1 (0.4–3.4) | 0.82 |
M2 |
1 | 16 | 0.6 (0.08–5.1) | 0.66 |
Wild type |
12
|
63
|
1.0 (Reference)
|
|
Mean age at PCP diagnosis, y
|
38.5
|
40.6
|
1.0
|
0.95
|
First-line treatment | ||||
Others |
3 | 19 | 0.4 (0.1–2.0) | 0.29 |
Sulfonamides |
15 | 75 | 1.0 (Reference) |
*PCP, Pneumocystis jirovecii pneumonia; RH, relative hazard; SSCP, single-strand conformation polymorphism; DHPS, dihydropteroate synthase; M, mutation.
†RH for death attributed to PCP after adjustment for the 5 variables presented in the table. The global p value of the test for proportionality was 0.55, and no individual test was statistically significant at the 0.05 level.