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Volume 19, Number 8—August 2013
Dispatch

Recombinant Coxsackievirus A2 and Deaths of Children, Hong Kong, 2012

Cyril C.Y. Yip, Susanna K.P. Lau, Patrick C.Y. Woo, Samson S.Y. Wong, Thomas H.F. Tsang, Janice Y.C. Lo, Wai-Kwok Lam, Chak-Chi Tsang, Kwok-Hung Chan, and Kwok-Yung YuenComments to Author 
Author affiliations: The University of Hong Kong, Hong Kong, China (C.C.Y. Yip, S.K.P. Lau, P.C.Y. Woo, S.S.Y. Wong, K.-H. Chan, K.Y. Yuen); Department of Health, Hong Kong (T.H.F. Tsang, J.Y.C. Lo, W.-K. Lam, C.-C. Tsang)

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Figure 2

Recombination analysis of complete genome of coxsackievirus A2 (CVA2), Hong Kong, 2012. A) Genome organization. B) Bootscanning and C) similarity plot analyses were conducted by using Simplot version 3.5.1 (http://sray.med.som.jhmi.edu/SCRoftware/simplot/) (Kimura distance model; window size, 400 bp; step, 20 bp) on a gapless nucleotide alignment generated with ClustalX 2.0 (8) with the genome sequence of CVA2 strain 430895 as the query sequence. In panel B, green line indicates CVA2 prototype s

Figure 2. . Recombination analysis of complete genome of coxsackievirus A2 (CVA2), Hong Kong, 2012. A) Genome organization. B) Bootscanning and C) similarity plot analyses were conducted by using Simplot version 3.5.1 (http://sray.med.som.jhmi.edu/SCRoftware/simplot/) (Kimura distance model; window size, 400 bp; step, 20 bp) on a gapless nucleotide alignment generated with ClustalX 2.0 (8) with the genome sequence of CVA2 strain 430895 as the query sequence. In panel B, green line indicates CVA2 prototype strain Fleetwood, red line indicates EV71 strain SAR/SHA66 of subgenotype B3, yellow line indicates EV71 strain SZ/HK08–5 of subgenotype C4, and blue line indicates CVA4 strain SZ/CHN/09. P1, capsid protein 1, P2, nonstructural protein 2; P3, nonstructural protein 3; UTR, untranslated region; VP, viral protein.

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