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Volume 26, Number 3—March 2020
CME ACTIVITY - Synopsis

Clinical Characteristics of Disseminated Strongyloidiasis, Japan, 1975–2017

Mitsuru MukaigawaraComments to Author , Masashi Narita, Soichi Shiiki, Yoshihiro Takayama, Shunichi Takakura, and Tomokazu Kishaba
Author affiliations: Harvard Kennedy School, Cambridge, Massachusetts, USA (M. Mukaigawara); Okinawa Chubu Hospital, Uruma, Okinawa, Japan (M. Mukaigawara, M. Narita, S. Shiiki, Y. Takayama, S. Takakura, T. Kishaba)

Main Article

Table 4

Involvement of larvae and enteric organisms in disseminated strongyloidiasis reported in previous studies*

Characteristic Dissemination Occult dissemination with meningitis/enteric organisms Occult dissemination with culture-negative suppurative meningitis
Involvement of larvae
 Confirmed (rhabditiform and filariform larvae)
 Confirmed (rhabditiform larvae)
 Confirmed (rhabditiform larvae)
Involvement of enteric organisms Confirmed Confirmed Not detected

*References 11, 14, and 15.

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References
  1. Olsen  A, van Lieshout  L, Marti  H, Polderman  T, Polman  K, Steinmann  P, et al. Strongyloidiasis—the most neglected of the neglected tropical diseases? Trans R Soc Trop Med Hyg. 2009;103:967–72. DOIPubMedGoogle Scholar
  2. Igra-Siegman  Y, Kapila  R, Sen  P, Kaminski  ZC, Louria  DB. Syndrome of hyperinfection with Strongyloides stercoralis. Rev Infect Dis. 1981;3:397–407. DOIPubMedGoogle Scholar
  3. Fardet  L, Généreau  T, Poirot  JL, Guidet  B, Kettaneh  A, Cabane  J. Severe strongyloidiasis in corticosteroid-treated patients: case series and literature review. J Infect. 2007;54:18–27. DOIPubMedGoogle Scholar
  4. Marty  FM. Strongyloides hyperinfection syndrome and transplantation: a preventable, frequently fatal infection. Transpl Infect Dis. 2009;11:97–9. DOIPubMedGoogle Scholar
  5. Sánchez  PR, Guzman  AP, Guillen  SM, Adell  RI, Estruch  AM, Gonzalo  IN, et al. Endemic strongyloidiasis on the Spanish Mediterranean coast. QJM. 2001;94:357–63. DOIPubMedGoogle Scholar
  6. Keiser  PB, Nutman  TB. Strongyloides stercoralis in the immunocompromised population. Clin Microbiol Rev. 2004;17:208–17. DOIPubMedGoogle Scholar
  7. US Centers for Disease Control and Prevention. Parasites: Strongyloides. Biology [cited 2019 Feb 1]. https://www.cdc.gov/parasites/strongyloides/biology.html
  8. Mansfield  LS, Alavi  A, Wortman  JA, Schad  GA. Gamma camera scintigraphy for direct visualization of larval migration in Strongyloides stercoralis-infected dogs. Am J Trop Med Hyg. 1995;52:236–40. DOIPubMedGoogle Scholar
  9. Pukkila-Worley  R, Nardi  V, Branda  JA. Case records of the Massachusetts General Hospital. Case 28-2014. A 39-year-old man with a rash, headache, fever, nausea, and photophobia. N Engl J Med. 2014;371:1051–60. DOIPubMedGoogle Scholar
  10. Kishaba  T. Disseminated strongyloidiasis. In: Shiroma Y, Sato Y, editors. Strongyloides stercoralis and strongyloidiasis in Japan [in Japanese]. Fukuoka (Japan): Kyushu University Press; 1997. p. 55–78.
  11. Kishaba  T. Strongyloidiasis and infections due to enteric organisms: sepsis, pneumonia and meningitis caused by Gram-negative bacteria associated with disseminated strongyloidiasis [in Japanese]. Infection. 1982;12:180.
  12. Jain  AK, Agarwal  SK, el-Sadr  W. Streptococcus bovis bacteremia and meningitis associated with Strongyloides stercoralis colitis in a patient infected with human immunodeficiency virus. Clin Infect Dis. 1994;18:253–4. DOIPubMedGoogle Scholar
  13. Chu  E, Whitlock  WL, Dietrich  RA. Pulmonary hyperinfection syndrome with Strongyloides stercoralis. Chest. 1990;97:1475–7. DOIPubMedGoogle Scholar
  14. Kishaba  T, Uchihara  T, Ueno  K, Goeku  C, Shimabukuro  Y. Gram-negative rod meningitis probably caused by occult disseminated strongyloidiasis [in Japanese]. Okinawa Medical Journal. 1985;22:3.
  15. Kishaba  T, Suginohara  K, Tamaki  K, Miyara  Y, Endo  K, Taira  Y, et al. Culture negative suppurative meningitis probably caused by occult disseminated strongyloidiasis [in Japanese]. Okinawa Medical Journal. 1989;26:219.
  16. Mukaigawara  M, Nakayama  I, Gibo  K. Strongyloidiasis and culture-negative suppurative meningitis, Japan, 1993–2015. Emerg Infect Dis. 2018;24:2378–80. DOIPubMedGoogle Scholar
  17. Sasaki  Y, Taniguchi  T, Kinjo  M, McGill  RL, McGill  AT, Tsuha  S, et al. Meningitis associated with strongyloidiasis in an area endemic for strongyloidiasis and human T-lymphotropic virus-1: a single-center experience in Japan between 1990 and 2010. Infection. 2013;41:1189–93. DOIPubMedGoogle Scholar
  18. Shimasaki  T, Chung  H, Shiiki  S. Five cases of recurrent meningitis associated with chronic strongyloidiasis. Am J Trop Med Hyg. 2015;92:601–4. DOIPubMedGoogle Scholar
  19. Toma  H, Shimabukuro  I, Kobayashi  J, Tasaki  T, Takara  M, Sato  Y. Community control studies on Strongyloides infection in a model island of Okinawa, Japan. Southeast Asian J Trop Med Public Health. 2000;31:383–7.PubMedGoogle Scholar
  20. Sagara  Y, Iwanaga  M, Morita  M, Sagara  Y, Nakamura  H, Hirayama  H, et al. Fine-scale geographic clustering pattern of human T-cell leukemia virus type 1 infection among blood donors in Kyushu-Okinawa, Japan. J Med Virol. 2018;90:1658–65. DOIPubMedGoogle Scholar
  21. Cresci  GA, Bawden  E. Gut microbiome: what we do and don’t know. Nutr Clin Pract. 2015;30:734–46. DOIPubMedGoogle Scholar
  22. Scowden  EB, Schaffner  W, Stone  WJ. Overwhelming strongyloidiasis: an unappreciated opportunistic infection. Medicine (Baltimore). 1978;57:527–44. DOIPubMedGoogle Scholar
  23. Tomori  M, Mukaigawara  M, Narita  M. Acute esophageal necrosis associated with Strongyloides stercoralis hyperinfection. Am J Trop Med Hyg. 2019;100:1037–8. DOIPubMedGoogle Scholar
  24. Geri  G, Rabbat  A, Mayaux  J, Zafrani  L, Chalumeau-Lemoine  L, Guidet  B, et al. Strongyloides stercoralis hyperinfection syndrome: a case series and a review of the literature. Infection. 2015;43:691–8. DOIPubMedGoogle Scholar
  25. Tanaka  T, Hirata  T, Parrott  G, Higashiarakawa  M, Kinjo  T, Kinjo  T, et al. Relationship among Strongyloides stercoralis infection, human T-cell lymphotropic virus type 1 infection, and cancer: a 24-year cohort inpatient study in Okinawa, Japan. Am J Trop Med Hyg. 2016;94:365–70. DOIPubMedGoogle Scholar
  26. Schär  F, Trostdorf  U, Giardina  F, Khieu  V, Muth  S, Marti  H, et al. Strongyloides stercoralis: global distribution and risk factors. PLoS Negl Trop Dis. 2013;7:e2288. DOIPubMedGoogle Scholar
  27. Teixeira  MC, Pacheco  FT, Souza  JN, Silva  ML, Inês  EJ, Soares  NM. Strongyloides stercoralis infection in alcoholic patients. BioMed Res Int. 2016;2016:4872473. DOIPubMedGoogle Scholar
  28. de Oliveira  LC, Ribeiro  CT, Mendes  DM, Oliveira  TC, Costa-Cruz  JM. Frequency of Strongyloides stercoralis infection in alcoholics. Mem Inst Oswaldo Cruz. 2002;97:119–21. DOIPubMedGoogle Scholar
  29. Gotuzzo  E, Terashima  A, Alvarez  H, Tello  R, Infante  R, Watts  DM, et al. Strongyloides stercoralis hyperinfection associated with human T cell lymphotropic virus type-1 infection in Peru. Am J Trop Med Hyg. 1999;60:146–9. DOIPubMedGoogle Scholar
  30. Hays  R, Esterman  A, McDermott  R. Type 2 diabetes mellitus is associated with Strongyloides stercoralis treatment failure in Australian aboriginals. PLoS Negl Trop Dis. 2015;9:e0003976. DOIPubMedGoogle Scholar
  31. Henriquez-Camacho  C, Gotuzzo  E, Echevarria  J, White  AC Jr, Terashima  A, Samalvides  F, et al. Ivermectin versus albendazole or thiabendazole for Strongyloides stercoralis infection. Cochrane Database Syst Rev. 2016; (1):CD007745. DOIPubMedGoogle Scholar
  32. Zaha  O, Hirata  T, Kinjo  F, Saito  A, Fukuhara  H. Efficacy of ivermectin for chronic strongyloidiasis: two single doses given 2 weeks apart. J Infect Chemother. 2002;8:94–8. DOIPubMedGoogle Scholar
  33. Mejia  R, Nutman  TB. Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis. Curr Opin Infect Dis. 2012;25:458–63. DOIPubMedGoogle Scholar
  34. Tarr  PE, Miele  PS, Peregoy  KS, Smith  MA, Neva  FA, Lucey  DR. Case report: Rectal adminstration of ivermectin to a patient with Strongyloides hyperinfection syndrome. Am J Trop Med Hyg. 2003;68:453–5. DOIPubMedGoogle Scholar
  35. Barrett  J, Broderick  C, Soulsby  H, Wade  P, Newsholme  W. Subcutaneous ivermectin use in the treatment of severe Strongyloides stercoralis infection: two case reports and a discussion of the literature. J Antimicrob Chemother. 2016;71:220–5. DOIPubMedGoogle Scholar
  36. Marty  FM, Lowry  CM, Rodriguez  M, Milner  DA, Pieciak  WS, Sinha  A, et al. Treatment of human disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin. Clin Infect Dis. 2005;41:e5–8. DOIPubMedGoogle Scholar
  37. Pornsuriyasak  P, Niticharoenpong  K, Sakapibunnan  A. Disseminated strongyloidiasis successfully treated with extended duration ivermectin combined with albendazole: a case report of intractable strongyloidiasis. Southeast Asian J Trop Med Public Health. 2004;35:531–4.PubMedGoogle Scholar
  38. Kishimoto  K, Hokama  A, Hirata  T, Ihama  Y, Nakamoto  M, Kinjo  N, et al. Endoscopic and histopathological study on the duodenum of Strongyloides stercoralis hyperinfection. World J Gastroenterol. 2008;14:1768–73. DOIPubMedGoogle Scholar

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Page created: February 19, 2020
Page updated: February 19, 2020
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