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Volume 28, Supplement—December 2022
SUPPLEMENT ISSUE
Synopsis

Effectiveness of Whole-Virus COVID-19 Vaccine among Healthcare Personnel, Lima, Peru

Carmen S. ArriolaComments to Author , Giselle Soto, Matthew Westercamp, Susan Bollinger, Angelica Espinoza, Max Grogl, Alejandro Llanos-Cuentas, Eduardo Matos, Candice Romero, Maria Silva, Rachel Smith, Natalie Olson, Michael Prouty, Eduardo Azziz-Baumgartner, and Fernanda C. Lessa
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (C.S. Arriola, M. Westercamp, S. Bollinger, R. Smith, N. Olson, E. Azziz-Baumgartner, F.C. Lessa); Naval Medical Research Unit No. 6, Lima, Peru (G. Soto, A. Espinoza, M. Grogl, C. Romero, M. Silva, M. Prouty); Cayetano Heredia Hospital, Lima (A. Llanos-Cuentas); Arzobispo Loayza National Hospital, Lima (E. Matos)

Main Article

Table 1

Characteristics, vaccine receipt, and SARS-CoV-2 laboratory detection among 290 participants in a study on effectiveness of whole-virus COVID-19 vaccine among healthcare personnel, Lima, Peru, February 9–May 4, 2021*

Characteristics All workers SARS-CoV-2 testing†
Vaccination status‡
Positive Negative p value Unvaccinated Partially vaccinated p value Fully vaccinated p value
Total no. (%)
290 (100)
25 (9)
265 (91)
NA

20 (7)
54 (19)
NA
216 (74)
NA
Median age, y (IQR)
45 (38–52)
48 (41–54)
45 (38–51)
0.82

39 (37–49)
47 (39–52)
0.14
45 (39–52)
0.12
Age range, y
18–39 85 (29) 6 (24) 79 (30) NA 10 (50) 14 (26) NA 61 (28) NA
40–49 110 (38) 10 (40) 100 (38) NA 5 (25) 22 (41) NA 83 (38) NA
50–65
95 (33)
9 (36)
86 (32)
NA

5 (25)
18 (33)
NA
72 (33)
NA
Sex
M 75 (26) 6 (24) 69 (26) 1.0 1 (5) 25 (46) <0.01 49 (23) 0.12
F
215 (74)
10 (76)
196 (74)
NA

19 (95)
29 (54)
NA
167 (77)
NA
Race/ethnicity
Mixed race 260 (90) 21 (84) 239 (90) 0.45 19 (95) 45 (83) 0.48 196 (91) 0.89
Indigenous 19 (7) 2 (8) 17 (6) NA 1 (5) 3 (6) NA 15 (7) NA
Black 8 (3) 1 (4) 7 (3) NA 0 5 (9) NA 3 (1) NA
White
3 (1)
1 (4)
2 (1)
NA

0
1 (2)
NA
2 (1)
NA
Education
High school only 37 (13) 2 (8) 35 (13) 0.75 0 13 (24) 0.02 24 (11) 0.10
Associate or bachelor’s degree 233 (80) 21 (84) 212 (80) NA 20 (100) 38 (70) NA 175 (81) NA
Postgraduate education
20 (7)
2 (8)
18 (7)
NA

0
3 (6)
NA
17 (8)
NA
Comorbidities
Any medical condition§ 8 (3) 2 (8) 6 (2) 0.52 1 (5) 2 (4) 0.74 5 (2) 0.64
BMI¶
Normal 83 (29) 9 (36) 74 (28) 0.61 9 (45) 17 (31) 0.47 57 (26) 0.20
Overweight 143 (49) 12 (48) 131 (49) NA 7 (35) 27 (50) NA 109 (50) NA
Obese 64 (22) 4 (16) 60 (23) NA 4 (20) 10 (19) NA 50 (23) NA
Smoking daily/some
11 (4)
1 (4)
10 (4)
1.0

1 (5)
3 (6)
1.0
7 (3)
1.0
Job type
Physician 11 (4) 1 (4) 10 (4) 0.62 0 0 <0.01 11 (5) 0.08
Nurse 63 (22) 2 (8) 61 (23) NA 1 (5) 10 (19) NA 52 (24) NA
Midwife or dentist 12 (4) 1 (4) 11 (4) NA 0 0 NA 12 (5) NA
Technician, assistant 135 (47) 14 (56) 121 (46) NA 15 (75) 17 (31) NA 103 (48) NA
Pharmacist, social worker, nutritionist 2 (1) 0 2 (1) NA 1 (5) 0 NA 1 (0) NA
Physical therapist 4 (1) 0 4 (2) NA 0 2 (4) NA 2 (1) NA
Administrator, security, maintenance, transporter 49 (17) 7 (28) 42 (15) NA 1 (5) 20 (37) NA 28 (12) NA
Other
14 (5)
0
14 (5)
NA

2 (10)
5 (9)
NA
7 (3)
NA
Exposed to COVID-19 patients in healthcare setting 249 (86) 18 (72) 231 (87) 0.59 17 (85) 45 (83) 1.0 187 (87) 1.0
ICU 27 (9) 4 (16) 23 (9) 0.40 0 8 (15) 0.16 19 (9) 0.34
ED
101 (35)
11 (44)
90 (34)
0.43

9 (45)
20 (37)
0.72
72 (33)
0.42
Median hours worked at site/week (IQR) 36 (36–36) 36 (36–40) 36 (36–36) 0.93 36 (36–39) 36 (36–48) 0.23 36 (36–36) 0.40
Median hours patient-provider face-to-face/week (IQR) 30 (24–36) 30 (20–30) 30 (25–36) 0.04 33 (30–37) 30 (25–36) 0.31 30 (24–36) 0.11
Reactive SARS-CoV-2 serology at baseline 106 (37) 0 106 (40) <0.01 5 (25) 15 (28) 1.0 86 (40) 0.28

*Values represent no. (%) unless otherwise indicated. p values were calculated by using χ2 test for categorical and Wilcoxon signed rank test for continuous variables. BMI, body mass index; ED, emergency department; ICU, intensive care unit. †At least once by weekly testing during follow-up period. ‡Vaccination of healthcare workers started in Lima on February 9, 2021, and was assessed by interview on a weekly basis. Partially vaccinated refers to persons who received 1 dose of whole-virus COVID-19 vaccine during the study period; fully vaccinated refers to persons who received 2 doses of whole-virus COVID-19 vaccine during the study period. Partially and fully vaccinated groups were separately compared against unvaccinated persons. §Asthma, diabetes, high blood pressure, chronic heart disease, autoimmune condition, HIV/AIDS, another medical condition requiring clinical care >6 mo. ¶Normal (18.5 to <25); overweight (25 to <30); obese (>30).

Main Article

Page created: August 23, 2022
Page updated: August 23, 2022
Page reviewed: August 23, 2022
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