Volume 30, Number 4—April 2024
Research
Divergent Pathogenesis and Transmission of Highly Pathogenic Avian Influenza A(H5N1) in Swine
Bailey Arruda
, Amy L. Vincent Baker, Alexandra Buckley, Tavis K. Anderson, Mia Torchetti, Nichole Hines Bergeson, Mary Lea Killian, and Kristina Lantz
, Amy L. Vincent Baker, Alexandra Buckley, Tavis K. Anderson, Mia Torchetti, Nichole Hines Bergeson, Mary Lea Killian, and Kristina Lantz
Table 2
Replication and transmission data in study of divergent pathogenesis and transmission of highly pathogenic avian influenza A(H5N1) in swine*
| Strain | Inoculated pigs |
Contact pigs |
|||||
|---|---|---|---|---|---|---|---|
| NS PCR-positive | BALF PCR-positive, 3 dpi | BALF PCR-positive, 5 dpi | Seroconversion | NS PCR-positive | Seroconversion | ||
| A/turkey/MN/22 | 0/15 | 3/5 | 3/5 | 2/5 | 0/5 | 0/5 | |
| A/bald eagle/FL/22 | 0/15 | 5/5 | 5/5 | 3/5 | 0/5 | 0/5 | |
| A/raccoon/WA/22 | 4/15 | 4/5 | 5/5 | 5/5 | 2/5 | 1/5 | |
| A/red fox/MI/22 | 5/15 | 5/5 | 4/5 | 5/5 | 0/5 | 1/5 | |
*Nasal swab samples were taken on 0, 1, 3, 5, and 7 dpi or dpc. BALF was collected at 3 and 5 dpi. Influenza A virus qRT-PCR. Seroconversion results of inoculated pigs are only on surviving pigs at ≈2 weeks dpi or dpc. BALF, bronchoalveolar lavage fluid; dpc, days postcontact; dpi, days postinoculation; NS, nasal swab; qRT-PCR, quantitative reverse transcription PCR.
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