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Volume 30, Number 9—September 2024
Research Letter

Association of Intestinal Helminthiasis with Disseminated Leishmaniasis, Brazil

Brady PageComments to Author , Alexsandro Lago, and Edgar M. Carvalho
Author affiliations: University of California–San Diego, La Jolla, California, USA (B. Page); Scripps Research Institute, La Jolla (B. Page); Universidade Federal da Bahia, Salvador, Brazil (A. Lago, E.M. Carvalho); Instituto Nacional de Ciências e Tecnologia para Doenças Tropicais, Brasília, Brazil (E.M. Carvalho); Fundação Oswaldo Cruz, Salvador (E.M. Carvalho)

Main Article

Table

Comparison of characteristics of patients with cutaneous and disseminated leishmaniasis, with and without intestinal helminthiasis, Brazil, 2017

Characteristic All patients
 Patients with disseminated leishmaniasis
Cutaneous leishmaniasis Disseminated leishmaniasis p value With intestinal helminthiasis Without intestinal helminthiasis p value
Total no. patients
 99
 30
8
 12
Median age, y (range)
 24 (13–56)
 42 (18–69)
 0.02*
37.5 (24–65)
 49.5 (18–69)
 0.6*
Sex, no. (%)
M 76 (76.8) 15 (75) 1† 6 (75) 8 (67) 1†
F
 23 (23.4)
 5 (25)
2 (25)
 4 (33)
Median duration of illness, d (range)
 40 (20–60)
 30 (15–90)
 0.18*
40 (20–90)
 30 (15–90)
 0.43*
Median no. lesions (range) 1 (1–8) 35.5 (11–1,500) <0.05* 46 (11–1,500) 27 (12–102) 0.8*
Median area of largest lesion, mm2 (range)
 224 (15–3,016)
 260.5 (16–16,160)
 0.3*
240 (36–16,160)
 260.5 (16–1,280)
 0.57*
Helminths present, % (no.) 40 (40/99) 40 (8/20) 1†
Median no. helminth ova present on fecal microscopy (range)
 6 (1–4,000)
 60 (1–288)
 0.08*
Cure rate at 90 d, % (no. patients) 65.9 (60/91) 30 (6/20) 0.003* 25 (2/8) 33 (4/12) 0.78*
Median time to cure, d (range) 65 (17–390) 154.5 (45–800) <0.001* 184.5 (60–800) 140 (45–540) 0.46*

*Significance assessed by Mann-Whitney U test. †Significance assessed by χ2 test.

Main Article

Page created: July 30, 2024
Page updated: August 21, 2024
Page reviewed: August 21, 2024
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