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Volume 13, Number 5—May 2007
Letter

Expanded-spectrum β-Lactamase and Plasmid-mediated Quinolone Resistance

Laurent Poirel*Comments to Author , Laura Villa†, Alessia Bertini†, Johann D. Pitout‡, Patrice Nordmann*, and Alessandra Carattoli†
Author affiliations: *Hôpital de Bicêtre, K.-Bicêtre, France; †University of Calgary, Calgary, Alberta, Canada; ‡Istituto Superiore di Sanita, Rome, Italy;

Main Article

Table

Features of the VEB-1– or QnrA-positive isolates used in this study*

Strain†/Ref. Spp. of origin Country Year of isolation Plasmid size (kb) ESBL QnrA1 Replicon Associated non–β-lactam resistance markers
Escherichia coli TcE1 (5)
 E. coli
 Thailand
 1999
 160
 VEB-1
 +
 A/C2
 NAL, K, SSS, C, RA
E. coli TcE4 (5)
 E. coli
 Thailand
 1999
 150
 VEB-1
 +
 A/C2
 NAL, K, TM, SSS, C, RA
E. coli TcE5 (5)
 E. coli
 Thailand
 1999
 150
 VEB-1
 +
 A/C2
 NAL, K, TM, SSS, SXT
E. coli TcE7 (5)
 E. coli
 Thailand
 1999
 150
 VEB-1
 +
 A/C2
 NAL, K, TM, SSS, C, RA
E. coli TcE8 (5)
 E. coli
 Thailand
 1999
 150
 VEB-1
 +
 A/C2
 NAL, K, TM, SSS, TE
E. coli TcE16 (5)
 E. coli
 Thailand
 1999
 140
 VEB-1
 +
 A/C2
 NAL, K, TM, SSS, RA
E. coli TcE18 (5)
 E. coli
 Thailand
 1999
 180
 VEB-1
 +
 A/C2
 NAL, K, SSS, C, RA
E. coli Tc(pl) (5)
 E. coli
 Canada
 2000
 180
 VEB-1
 +
 A/C2
 NAL, K, SSS, C, RA
E. coli Tc(pQR1) (4)
 E. coli
 France
 2003
 180
 VEB-1
 +
 A/C2
 NAL, K, SSS, C, RA, SXT
E. coli Tc(GOC) (4)
 Enterobacter cloacae
 France
 2003
 190
 VEB-1
 +
 A/C2, FIB
 NAL, K, TM, SSS, C
Citrobacter freundii LUT (3)
 C. freundii
 Turkey
 2004
 ND
 VEB-1
 +
 A/C2, FIB, K
 NA
Providencia stuartii 15 (this study)
 P. stuartii
 Algeria
 2004
 ND
 VEB-1
 –
 A/C2
 NA
E. coli TcMAA (this study)
 Proteus mirabilis
 Algeria
 2004
 190
 VEB-1
 –
 A/C2
 K, TM, SSS, C, SXT
E. coli TcK147 (7)
 Klebsiella pneumoniae
 Australia
 2002
 160
 SHV-12
 +
 HI2, A/C1, P
 NAL, K, TM, C, TE, SXT
E. cloacae A1 (8)
 E. cloacae
 France
 2004
 75
 SHV-12
 +
 HI2
 NA
E. coli TcA2 (8)
 Enterobacter aerogenes
 France
 2005
 150
 SHV-12
 +
 FII
 NAL, K, TM, TE
E. coli TcA3 (8) K. pneumoniae France 2005 40 – + I1, K NAL, K, TM, C, TE

*Ref., reference; ESBL, extended-spectrum β-lactamase; NAL, nalidixic acid; K, kanamycin; SSS, sulfonamides; C, chloramphenicol; RA, rifampin; TM, tobramycin; SXT, trimethoprim-sulfamethoxazole; TE, tetracycline; ND, not determinable; NA, not applicable.
†Tc indicates that this is a transconjugant or a transformant.

Main Article

References
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