Volume 1, Number 4—October 1995
Dispatch
Helicobacter hepaticus, a Recently Recognized Bacterial Pathogen, Associated with Chronic Hepatitis and Hepatocellular Neoplasia in Laboratory Mice
Table
Increasing prevalence of hepatitis and hepatocellular neoplasia in control male A/JCr mice at the National Cancer Institute's Frederick Cancer Research and Development Center, 1989-1992a
| Date Killed | Number of mice | Age, in weeks | Mice with hepatitis (%) | Mice with liver tumors (%) |
|---|---|---|---|---|
| Jan-Mar 1989 | 48 | 47±3 | 0 | 0 |
| May-Jul 1989 | 47 | 70±360 | 0 | 1 (2) |
| Jan-Apr 1992 | 6 | 36±34 | 2 (33) | 0 |
| Jul 1992 | 16 | 54 | 16 (100) | 1 (6) |
| Aug-Oct 1992 | 64±3 | 5 (83) | 3 (50) | |
| Dec 1992 | 77 | 12 (100) | 11 (92) |
Adapted from ref. 4.
