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Volume 10, Number 11—November 2004

Research

Histopathologic Improvement with Lymphedema Management, Léogâne, Haiti

Susan F. Wilson*, Jeannette Guarner*, Alix L. Valme†, Jacky Louis-Charles†, Tara L. Jones*, and David G. Addiss*Comments to Author 
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Hôpital Ste. Croix, Léogâne, Haiti

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Table 2

Number and percentage of initial skin biopsy specimens in which histopathologic features were detected, by stage of lymphedema, Léogâne, Haiti

Location in skin Histopathologic characteristic Control
(N = 26)
n (%) Lymphedema
Stage 1
(N = 12)
n (%) Stage 2
(N = 60)
n (%) Stage 3
(N = 20)
n (%)
Epidermis Hyperkeratosis 4 (15) 5 (42) 23 (38)a 16 (80)b
Hypergranulosis 0 (0) 1 (8) 5 (8) 4 (20)a
Acanthosis 0 (0) 3 (25)a 11 (18)a 6 (30)c
Superficial dermis Fibrolamellar hyperplasia 5 (19) 6 (50) 25 (42)a 11 (55)a
Condensed collagen 0 (0) 1 (8) 18 (30)c 7 (35)c
Perivascular fibrosis 0 (0) 1 (8) 6 (10) 3 (15)
Perivascular infiltrate
   Acute 0 (0) 0 (0) 2 (3) 0 (0)
   Chronic 11 (42) 8 (67) 46 (77)c 19 (95)b
   Pronounced intensity 1 (4) 2 (17) 11 (18) 7 (35)c
   Presence of plasma cells 0 (0) 0 (0) 9 (15)a 6 (30)c
Deep dermis Perivascular fibrosis 3 (11) 1 (8) 16 (27) 8 (40)a
Perivascular infiltrate
   Acute 0 (0) 0 (0) 0 (0) 0 (0)
   Chronic 12 (46) 6 (50) 54 (90)b 19 (95)b
   Pronounced intensity 1 (4) 3 (25) 20 (33)c 11 (55)b
   Presence of plasma cells 1 (4) 7 (58)b 37 (62)b 15 (75)b
Periadnexal infiltrate
   Acute 0 (0) 0 (0) 0 (0) 0 (0)
   Chronic 4 (15) 4 (33) 36 (60)b 11 (55)c
   Pronounced intensity 0 (0) 0 (0) 10 (17)a 3 (15)
Subcutaneous tissue Infiltrate in fibrous septa
   Acute 0 (0) 0 (0) 0 (0) 0 (0)
   Chronic 1 (4) 3 (25) 19 (32)c 9 (45)c
   Pronounced intensity 1 (4) 3 (25) 5 (8) 3 (15)

ap < 0.05 (compared to control leg biopsy specimens).
bp < 0.001 (compared to control leg biopsy specimens).
cp < 0.01 (compared to control leg biopsy specimens).

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