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Volume 10, Number 12—December 2004

Research

Differential Virulence of West Nile Strains for American Crows

Aaron C. Brault*†Comments to Author , Stanley A. Langevin*, Richard A. Bowen‡, Nicholas A. Panella*, Brad J. Biggerstaff*, Barry R. Miller*, and Nicholas Komar*
Author affiliations: *Centers for Disease Control and Prevention, Fort Collins, Colorado, USA; †University of California, Davis, California, USA; ‡Colorado State University, Fort Collins, Colorado, USA

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Table 2

Clinical profile of American Crows infected with WNV strains NY99 (strain NY99-4132), KEN (strain KEN-3829), and KUN (strain KUN-6453)

Virus group Mortality:
no. died /N (%) Morbidity: no. ill/N (%) Mean day of death ± SD Mean peak viremiaa ± SD 
(mean duration ± SD) (n) Mean day of peak 
viremiaa ± SD
NY99 8/8 (100) 8/8 (100) 5.1 ± 0.6 9.2 ± 1.2 (4.2 ± 0.7) (8) 4.3 ± 0.9
KEN 1/8 (12.5) 2/8 (25) 9 ± NA 7.5 ± 0 (4.5 ± 0.7) (2) 5.0 ± 1.4
KEN-hdb 2/8 (25) 3/8 (38) 10.5 ± 2.1 4.8 ± 0.6 (3.1 ± 0.8) (8) 5.5 ± 0.9
KUN 0/8 0/8 NA 4.2 ± 0.8 (1.8 ± 0.5) (8) 3.3 ± 0.7
Control 0/8 0/8 NA NA NA

aViral titers were expressed as the log10 PFU/mL of crow sera as determined by plaque assay on Vero cells.
bhd, high-dose group (6,000 [3.8 log10] PFU); NA, not applicable.

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