Volume 10, Number 5—May 2004
Dispatch
Mycobacterium africanum Cases, California
Edward Desmond*
, Ameena T. Ahmed*, William S. Probert*, Janet Ely*, Yvonne Jang*, Cynthia A. Sanders*, Shou-Yean Lin*, and Jennifer Flood*
, Ameena T. Ahmed*, William S. Probert*, Janet Ely*, Yvonne Jang*, Cynthia A. Sanders*, Shou-Yean Lin*, and Jennifer Flood*Table 2
Phenotypic and molecular characteristics of Mycobacterium africanum isolates and country of birth for five patients
| Patient | No. of copies of IS6110 (bands) | Spoligo-typing pattern missing spacers 8,9,39? | OxyR285a | Codon katG463 sequenceb | Presence of RD9 deletion? | PZA susceptibilityc | Niacin pro-duction | Nitratereduc-tiond | Major site of disease | Birth country |
|---|---|---|---|---|---|---|---|---|---|---|
| A |
10 |
Yes |
G |
CTG |
Yes |
S |
+ |
3+ |
Lung |
South Africa |
| B |
3 |
Yes |
G |
CTG |
Yes |
S |
N.D.e |
N.D. |
Lung |
Ivory Coast |
| C |
9f |
Yes |
G |
CTG |
Yes |
S |
N.D. |
N.D. |
Lung |
South Africa |
| D |
11 |
Yes |
G |
CTG |
Yes |
S |
+ |
4+ |
Lung |
Vietnam |
| E | 9 | Yes | G | CTG | Yes | S | + | 3+ | Pancreas | USA |
aIsolates of M. bovis do not have G at this site.
bCTG is found in M. bovis and M. africanum, but not in most strains of M. tuberculosis.
cS, susceptible; PZA, pyrazinamide.
d3+ and 4+ reactions are considered positive.
eND, not done (because the culture lost viability).
fRestriction fragment length polymorphism patterns for isolates from patients C and E were identical.
