Volume 10, Number 5—May 2004
Research
Multidrug-resistant Tuberculosis in Central Asia
Helen Suzanne Cox*
, Juan Daniel Orozco*, Roy Male*, Sabine Ruesch-Gerdes†, Dennis Falzon*, Ian Small*, Darebay Doshetov‡, Yared Kebede§, and Mohammed Aziz¶
, Juan Daniel Orozco*, Roy Male*, Sabine Ruesch-Gerdes†, Dennis Falzon*, Ian Small*, Darebay Doshetov‡, Yared Kebede§, and Mohammed Aziz¶Table 2
First-line anti-tuberculosis drug resistance results, Karakalpakstan, Uzbekistana
| No. new cases (%) | No. retreatment cases (%) | Total no. (%) | |
|---|---|---|---|
| Total tested | 106 | 107 | 213 |
| Any resistance | 51 (48.1) | 86 (80.4) | 137 (64.3) |
| Monoresistance | |||
| H only | 3 (2.8) | 7 (6.5) | 10 (4.7) |
| R only | 0 | 0 | 0 |
| E only | 0 | 0 | 0 |
| S only | 12 (11.3) | 11 (10.3) | 23 (10.8) |
| Z only | 0 | 1 (0.9) | 1 (0.5) |
| H and R resistance | |||
| MDR | 14 (13.2) | 43 (40.2) | 57 (26.8) |
| HR only | 0 | 1 (0.9) | 1 (0.5) |
| HRE only | 0 | 0 | 0 |
| HRS only | 4 (3.8) | 10 (9.3) | 14 (6.6) |
| HRZ only | 0 | 0 | 0 |
| HRES only | 6 (5.7) | 19 (17.8) | 25 (11.7) |
| HREZ only | 0 | 0 | 0 |
| HRSZ only | 1 (0.9) | 0 | 1 (0.5) |
| HRESZ | 3 (2.8) | 13 (12.1) | 16 (7.5) |
| H + other resistance | |||
| HE only | 0 | 0 | 0 |
| HS only | 13 (12.3) | 15 (14.0) | 28 (13.1) |
| HZ only | 1 (0.9) | 1 | 2 (0.9) |
| HES only | 2 (1.9) | 4 (3.7) | 6 (2.8) |
| HEZ only | 0 | 0 | 0 |
| HSZ only | 1 (.9) | 3 (2.8) | 4 (1.9) |
| HESZ only | 5 (4.7) | 1 (0.9) | 6 (2.8) |
| R + other resistance | |||
| RE only | 0 | 0 | 0 |
| RS only | 0 | 0 | 0 |
| RZ only | 0 | 0 | 0 |
| RES only | 0 | 0 | 0 |
| RESZ only | 0 | 0 | 0 |
| Any drug resistance | |||
| Any H resistance | 39 (36.8) | 74 (69.2) | 113 (53.1) |
| Any R resistance | 14 (13.2) | 43 (40.2) | 57 (26.8) |
| Any E resistance | 16 (15.1) | 37 (34.6) | 53 (24.9) |
| Any S resistance | 47 (44.3) | 76 (71.0) | 123 (57.7) |
| Any Z resistance | 11 (10.4) | 19 (17.8) | 30 (14.1) |
aH, isoniazid; R, rifampin; E, ethambutol; S, streptomycin; Z, pyrizinamide.
