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Volume 10, Number 5—May 2004

Research

Multidrug-resistant Tuberculosis in Central Asia

Helen Suzanne Cox*Comments to Author , Juan Daniel Orozco*, Roy Male*, Sabine Ruesch-Gerdes†, Dennis Falzon*, Ian Small*, Darebay Doshetov‡, Yared Kebede§, and Mohammed Aziz¶
Author affiliations: *Médecins Sans Frontières Aral Sea Area Programme, Uzbekistan and Turkmenistan, Tashkent, Uzbekistan; †National Reference Centre for Mycobacteria, Borstel, Germany; ‡Ministry of Health, Nukus, Karakalpakstan, Uzbekistan; §Médecins Sans Frontières, Amsterdam, the Netherlands; ¶World Health Organization, Geneva, Switzerland

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Table 3

First-line anti-tuberculosis drug resistance results, Dashoguz, Turkmenistana

No. new cases (%) No. retreatment cases(%) Totalno. (%)
Total tested 105 98 203
Any resistance 32 (30.5) 61 (62.2) 93 (45.8)
Monoresistance
H only 6 (5.7) 8 (8.2) 14 (6.9)
R only 0 1 (1.0) 1 (0.5)
E only 0 0 0
S only 16 (15.2) 13 (13.3) 29 (14.3)
Z only 0 0 0
H and R resistance
MDR 4 (3.8) 18 (18.4) 22 (10.8)
HR only 0 0 0
HRE only 0 0 0
HRS only 3 (2.9) 7 (7.1) 10 (4.9)
HRZ only 0 0 0
HRES only 1 6 (6.1) 7 (3.4)
HREZ only 0 0 0
HRSZ only 0 3 (3.1) 3 (1.5)
HRESZ 0 2 (2.0) 2 (1.0)
H + other resistance
HE only 0 1 (1.0) 1 (0.5)
HS only 5 (4.8) 10 (10.2) 15 (7.4)
HZ only 0 1 (1.0) 1 (0.5)
HES only 1 (1.0) 6 (6.1) 7 (3.4)
HEZ only 0 0 0
HSZ only 0 3 (3.1) 3
HESZ only 0 0 0
R + other resistance
RE only 0 0 0
RS only 0 0 0
RZ only 0 0
RES only 0 0 0
RESZ only 0 0 0
Any drug resistance
Any H resistance 16 (15.2) 47 (48.0) 63
Any R resistance 4 (3.8) 19 (19.4) 23
Any E resistance 2 (1.9) 15 (15.3) 17
Any S resistance 26 (24.8) 50 (51.0) 76
Any Z resistance 0 9 (9.2) 9

aH, isoniazid; R, rifampin; E, ethambutol; S, streptomycin; Z, p, pyrizinamide.

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