Volume 10, Number 5—May 2004
Research
Genetic Variation of SARS Coronavirus in Beijing Hospital
Dongping Xu*, Zheng Zhang*, Fuliang Chu*, Yonggang Li*, Lei Jin*, Lingxia Zhang*, George F. Gao†, and Fu-Sheng Wang*
Table 2
Variation in S-gene sequences from 20 individual SARS patientsa,b
| Pt. no. | Samp. no. | 21494 |
21702 |
21858 |
22908 |
23198 |
24018 |
24247 |
24469 |
24540 |
|
|---|---|---|---|---|---|---|---|---|---|---|---|
| C→T | A→G | A→T | A→G | T→C | A→T | T→C | A→G | A→G | |||
| 1 |
SW6 |
– |
– |
– |
– |
– |
– |
– |
– |
– |
|
| 2 |
SW17 |
9/2c |
+ |
– |
– |
– |
– |
+ |
– |
– |
|
| 3 |
PL1 |
8/39 |
8/43 |
48/2 |
+ |
+ |
+ |
+ |
+ |
+ |
|
| 4 |
PL10 |
14/7 |
+ |
– |
+ |
+ |
2/8 |
+ |
+ |
+ |
|
| PL17 |
+ |
+ |
– |
– |
– |
+ |
+ |
+ |
+ |
||
| SP4 |
– |
+ |
– |
+ |
– |
+ |
+ |
+ |
+ |
||
| 5 |
PL9 |
+ |
+ |
– |
+ |
+ |
+ |
+ |
+ |
+ |
|
| SP1 |
– |
+ |
– |
+ |
+ |
– |
+ |
+ |
+ |
||
| 6 |
PL5 |
– |
+ |
– |
+ |
+ |
8/4 |
+ |
+ |
+ |
|
| SP9 |
– |
+ |
– |
+ |
+ |
+ |
+ |
+ |
+ |
||
| 7 |
PL7 |
– |
+ |
– |
+ |
+ |
4/6 |
+ |
+ |
+ |
|
| 8 |
PL8 |
7/28 |
+ |
33/2 |
+ |
+ |
+ |
+ |
+ |
+ |
|
| 9 |
SP15 |
– |
+ |
– |
– |
– |
– |
– |
– |
– |
|
| SP32 |
– |
+ |
– |
– |
– |
– |
– |
– |
– |
||
| 10 |
SP6 |
– |
– |
– |
– |
– |
– |
– |
– |
– |
|
| SP62 |
– |
– |
– |
– |
– |
– |
– |
– |
– |
||
| SW73 |
– |
– |
– |
– |
– |
– |
– |
– |
– |
||
| 11 |
SP67 |
– |
+ |
– |
– |
– |
– |
– |
– |
– |
|
| 12 |
SW76 |
– |
+ |
– |
– |
– |
– |
– |
– |
– |
|
| 13 |
ST123 |
– |
+ |
– |
– |
– |
– |
– |
– |
– |
|
| 14 |
PL57 |
– |
+ |
– |
– |
+ |
+ |
+ |
+ |
+ |
|
| SW77 |
– |
+ |
– |
– |
+ |
+ |
+ |
+ |
+ |
||
| 15 |
SP61 |
– |
+ |
– |
– |
– |
– |
– |
– |
– |
|
| 16 |
PL59 |
– |
– |
– |
– |
– |
– |
– |
– |
– |
|
| 17 |
SP28 |
– |
+ |
– |
– |
– |
– |
– |
– |
– |
|
| 18 |
SP43 |
– |
+ |
– |
– |
– |
– |
– |
– |
– |
|
| 19 |
ST158 |
– |
+ |
– |
+ |
+ |
+ |
+ |
+ |
+ |
|
| SP13 |
19/4 |
14/10 |
10/13 |
+ |
+ |
+ |
6/16 |
+ |
14/8 |
||
| 20 | SP8 | – | + | – | – | – | – | – | – | – | |
aThe results were determined by analysis of cloned sequences; + represents that nucleotide substitution at the variant site is detected and – represents that the nucleotide at the site is identical to the one of BJ01 reference sequence in all analyzed sequences.
bSARS, severe acute respiratory syndrome; SW, throat swab; PL, plasma; SP, sputum; ST, stool.
cThe numbers represent the ratio of reference to variant nucleotide detected at the site from the analyzed cloned sequences.
