Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 10, Number 6—June 2004

Research

Bovine Spongiform Encephalopathy Infectivity in Greater Kudu (Tragelaphus strepsiceros)

Andrew A. Cunningham*Comments to Author , James K. Kirkwood*1, Michael Dawson†2, Yvonne I. Spencer†, Robert B. Green†, and Gerald A.H. Wells†
Author affiliations: *Institute of Zoology, Regent’s Park, London, UK; †Veterinary Laboratories Agency, Addlestone, Surrey, UK; Bovine Spongiform Encephalopathy in Greater Kudu

Main Article

Table 2

Bioassay results for greater kudu tissues injected into C57Bl-J6 mice

Kudu identification Tissuea injected Positive mice/totalb Mean survival period post injection (days) ± SDc Survival period range (d)c
A1212
Rostral cerebrum
13/20
595±84
428–745

Cranial thoracic spinal cord
19/20d
557±121
413–821

Lumbar spinal cord
15/19
521±69
432–634

Spleen
3/11d
819±41
773–851

Retropharyngeal lymph node
6/11d
784±77
691–921

Popliteal lymph node
0/20d
N/Ae
N/A

Visceral lymph nodes (pool)
14/18
622±114
448–860

Submandibular lymph node
0/20d
N/A
N/A

Distal ileum
11/20
547±98
426–718

Lung
1/14d
N/A
746

Kidney
0/18
N/A
N/A

Caruncular endometrium
0/20d
N/A
N/A

Ovary
0/20
N/A
N/A

Mammary gland
0/20d
N/A
N/A

Submandibular salivary gland
1/17d
N/A
599

Conjunctiva
1/16d
N/A
659

Nasal mucosa
0/20
N/A
N/A

Skeletal muscle (biceps brachii + vastus lateralis)
0/19d
N/A
N/A

Skin (flank)
2/18d
713±22
697–728

Feces
0/11
N/A
N/A

Serum
0/19
N/A
N/A
A664
Spleen (P)
1/8d
N/A
929

Visceral lymph nodes (pool) (P)
6/15d
843±113
649–952

Lung (P)
0/20
N/A
N/A

Kidney (P)
0/20
N/A
N/A

Skeletal muscle (P)
0/19
N/A
N/A
A1221
Brainstem
10/18
634±62
541–762

Kidney
0/20
N/A
N/A

Skeletal muscle (vastus lateralis) (F)
0/19
N/A
N/A
A1221 + A666 (pool)
Spleen (pool)
0/20
N/A
N/A

Visceral lymph nodes (pool)
10/18
700±108
455–851
Lung (pool) (F) 0/19 N/A N/A

aTissues not prepared fresh are suffixed: (F), fixed, (P), paraffin wax embedded.
bNumber of mice positive/number of mice surviving when the first mouse was confirmed positive by histopathologic or immunochemical examination. The denominator for negative groups is the number of mice examined.
cSurvival periods of positive mice determined positive either by histopathologic or immunohistochemical examination results.
dMice examined by PrPSc immunohistochemical examinations.
eN/A, not applicable.

Main Article

1Present affiliation is Universities Federation for Animal Welfare, Wheathampstead, Hertfordshire, UK.

2Present affiliation is National Scrapie Plan Administration Centre, Worcester, UK.

Top of Page

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO