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Volume 10, Number 6—June 2004

Research

Bovine Spongiform Encephalopathy Infectivity in Greater Kudu (Tragelaphus strepsiceros)

Andrew A. Cunningham*Comments to Author , James K. Kirkwood*1, Michael Dawson†2, Yvonne I. Spencer†, Robert B. Green†, and Gerald A.H. Wells†
Author affiliations: *Institute of Zoology, Regent’s Park, London, UK; †Veterinary Laboratories Agency, Addlestone, Surrey, UK; Bovine Spongiform Encephalopathy in Greater Kudu

Main Article

Table 3

Details of spongiform encephalopathy–positive greater kudu used for mouse inoculation studies

Kudu Ref. Age at death (mo.) Sex Brief history Basis of diagnosis
A664
30
F
Born at London Zoo. Died after progressive neurologic disease of approximately 72 hours. Examined postmortem on the same day.
Histopathologic examination of brain and experimental transmission to mice.
A666
37
M
Born at London Zoo. Killed after progressive neurologic disease of approximately 24 hours. Examined postmortem on the same day.
Histopathologic, SAF, and PrPsc immunocytochemical examinations of the brain and spinal cord.a
A1221
18
M
Born at London Zoo. Killed for management reasons as a clinically healthy animal and immediately examined postmortem.
Histopathologic, SAF, and PrPsc immunocytochemical examinations of the brain and spinal cord.
A1212 39 F Born in Britain, moved to London Zoo at 12 months of age. Killed following progressive neurologic disease lasting approximately 1 month and immediately examined postmortem. Histopathologic and SAF examinations of the brain.

aSAF, scrapie-associated fibrils; PrPSc, transmissible spongiform encephalopathy-disease specific form of the PrP protein.

Main Article

1Present affiliation is Universities Federation for Animal Welfare, Wheathampstead, Hertfordshire, UK.

2Present affiliation is National Scrapie Plan Administration Centre, Worcester, UK.

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