Volume 10, Number 7—July 2004
Research
Fluoroquinolone and Other Antimicrobial Resistance in Invasive Pneumococci, Hong Kong, 1995–2001
Pak-Leung Ho*
, Tak-Lun Que†, Susan S. Chiu*, Raymond W. H. Yung†, Tak-Keung Ng§, Dominic N. C. Tsang¶, Wing-Hong Seto*, and Yu-Lung Lau*
, Tak-Lun Que†, Susan S. Chiu*, Raymond W. H. Yung†, Tak-Keung Ng§, Dominic N. C. Tsang¶, Wing-Hong Seto*, and Yu-Lung Lau*Table 1
MICs of 11 antimicrobial agents for Streptococcus pneumoniae isolates based on susceptibility to penicillina,b
| Antimicrobial agent and penicillin susceptibility status |
MIC (μg/mL) |
% of Isolates |
|||||
| Range |
50% |
90% |
Mode |
S |
I |
R |
|
| Penicillin |
|||||||
| All |
0.008−4 |
0.032 |
2 |
0.016 |
62.6 |
20.0 |
17.4 |
| Pen-S |
0.008−0.064 |
0.016 |
0.032 |
0.016 |
100 |
0.0 |
0.0 |
| Pen-I |
0.125−1 |
1 |
1 |
1 |
0.0 |
100 |
0.0 |
| Pen-R |
2−4 |
2 |
2.0 |
2 |
0.0 |
0.0 |
100 |
| Amoxicillin |
|||||||
| All |
0.016−4 |
0.032 |
2 |
0.016 |
99.6 |
0.4 |
0.0 |
| Pen-S |
0.016−0.125 |
0.016 |
0.032 |
0.016 |
100.0 |
0.0 |
0.0 |
| Pen-I |
0.032−2 |
1 |
2 |
1 |
100.0 |
0.0 |
0.0 |
| Pen-R |
0.5−4 |
2 |
2 |
2 |
97.8 |
2.2 |
0.0 |
| Cefotaxime |
|||||||
| All |
0.016−4 |
0.032 |
1 |
0.016 |
97.0 |
2.6 |
0.4 |
| Pen-S |
0.016−0.125 |
0.016 |
0.032 |
0.016 |
100.0 |
0.0 |
0.0 |
| Pen-I |
0.032−2 |
1 |
1 |
1 |
100.0 |
0.0 |
0.0 |
| Pen-R |
0.5−4 |
1 |
2 |
1 |
82.6 |
15.2 |
2.2 |
| Cefepime |
|||||||
| All |
0.016−4 |
0.064 |
2 |
0.064 |
76.2 |
21.9 |
1.9 |
| Pen-S |
0.016−0.25 |
0.064 |
0.125 |
0.064 |
100.0 |
0.0 |
0.0 |
| Pen-I |
0.032−1 |
1 |
2 |
2 |
66.0 |
34.0 |
0.0 |
| Pen-R |
1−4 |
2 |
2 |
2 |
2.2 |
87 |
10.9 |
| Clarithromycin |
|||||||
| All |
0.032−256 |
4 |
256 |
256 |
36.6 |
0.4 |
63.0 |
| Pen-S |
0.032−256 |
0.125 |
256 |
0.125 |
56.0 |
0.0 |
44.0 |
| Pen-I |
0.064−256 |
256 |
256 |
256 |
7.5 |
1.9 |
90.6 |
| Pen-R |
2−256 |
4 |
256 |
2 |
0.0 |
0.0 |
100.0 |
| Vancomycin |
|||||||
| All |
0.25−1 |
0.5 |
0.5 |
0.5 |
100.0 |
0.0 |
0.0 |
| Pen-S |
0.25−1 |
0.5 |
0.5 |
0.5 |
100.0 |
0.0 |
0.0 |
| Pen-I |
0.25−1 |
0.5 |
0.5 |
0.5 |
100.0 |
0.0 |
0.0 |
| Pen-R |
0.25−1 |
0.5 |
1 |
0.5 |
100.0 |
0.0 |
0.0 |
| Ciprofloxacin |
|||||||
| All |
0.25−32 |
1 |
1 |
1 |
95.8 |
− |
4.2 |
| Pen-S |
0.25−4 |
1 |
1 |
1 |
99.4 |
− |
0.6 |
| Pen-I |
0.25−32 |
1 |
1 |
1 |
94.3 |
− |
5.7 |
| Pen-R |
0.5−32 |
1 |
32 |
1 |
84.8 |
− |
15.2 |
| Levofloxacin |
|||||||
| All |
0.125−32 |
1 |
1 |
1 |
96.2 |
0.0 |
3.8 |
| Pen-S |
0.125−2 |
1 |
1 |
1 |
100.0 |
0.0 |
0.0 |
| Pen-I |
0.125−32 |
1 |
1 |
1 |
94.3 |
0.0 |
5.7 |
| Pen-R |
0.5−32 |
1 |
32 |
1 |
84.8 |
0.0 |
15.2 |
| Sparfloxacin |
|||||||
| All |
0.125−32 |
0.25 |
0.5 |
0.5 |
95.8 |
0.8 |
3.2 |
| Pen-S |
0.125−1 |
0.25 |
0.5 |
0.5 |
99.4 |
0.6 |
0.0 |
| Pen-I |
0.125−32 |
0.25 |
0.5 |
0.5 |
94.3 |
0.0 |
5.7 |
| Pen-R |
0.25−32 |
0.5 |
32 |
0.5 |
84.8 |
2.2 |
13.0 |
| Gatifloxacin |
|||||||
| All |
0.064−16 |
0.25 |
0.25 |
0.25 |
96.2 |
0.8 |
3.0 |
| Pen-S |
0.064−1 |
0.25 |
0.25 |
0.25 |
100.0 |
0.0 |
0.0 |
| Pen-I |
0.125−8 |
0.25 |
0.25 |
0.25 |
94.3 |
1.9 |
3.8 |
| Pen-R |
0.125−16 |
0.25 |
8 |
0.25 |
84.8 |
2.2 |
13.0 |
| Moxifloxacin |
|||||||
| All |
0.064−8 |
0.125 |
0.25 |
0.125 |
97.0 |
0.8 |
2.3 |
| Pen-S |
0.064−1 |
0.125 |
0.25 |
0.125 |
100.0 |
0.0 |
0.0 |
| Pen-I |
0.064−4 |
0.125 |
0.25 |
0.125 |
96.2 |
1.9 |
1.9 |
| Pen-R | 0.125−8 | 0.125 | 4 | 0.125 | 87.0 | 2.2 | 10.9 |
aN = 265; a total of 166 isolates were penicillin-susceptible (Pen-S), 53 were penicillin-intermediate (Pen-I), and 46 were penicillin-resistant (Pen-R).
b50% and 90%, MIC50 and MIC90, respectively.
