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Volume 10, Number 7—July 2004

Research

Fluoroquinolone and Other Antimicrobial Resistance in Invasive Pneumococci, Hong Kong, 1995–2001

Pak-Leung Ho*Comments to Author , Tak-Lun Que†, Susan S. Chiu*, Raymond W. H. Yung†, Tak-Keung Ng§, Dominic N. C. Tsang¶, Wing-Hong Seto*, and Yu-Lung Lau*
Author affiliations: *Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), China; †Tuen Mun Hospital, Hong Kong SAR, China; ‡Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China; §Princess Margaret Hospital, Hong Kong, SAR, China; ¶Queen Elizabeth Hospital, Hong Kong SAR, China

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Table 3

Characteristics of 11 strains of Streptococcus pneumoniae with reduced susceptibility to ciprofloxacin

Strain
Y
Source
Serotypea
MLST profile
MIC (μg/mL)
Mutation in QRDR ofcd





CIP
LVX
GAT
MO
GyrA
ParC
ParE
S3F7
1996
A
23F
4-4-2-4-4-1-1
32
32
2
1
S81F
K137N
E474K, I460V
S2H9
1997
A
23F
4-4-2-4-4-1-1
32
32
4
2
S81Y
K137N
D435N, I460V
S1B7
1999
B
23F
4-4-2-4-4-1-1
32
32
8
4
S81F
S79F, K137N
I460V
S1B9
1999
B
23F
4-4-2-4-4-1-1
32
32
16
4
S81F
S79F, K137N
I460V
S1D5
1999
C
19F
4-4-2-4-4-1-1
32
32
8
4
S81F
S79F, K137N
I460V
S2D6
1999
A
14
4-4-2-4-4-1-1
32
32
8
4
S81F
S79F, K137N
I460V
S1D2
2000
C
19F
4-4-2-4-4-1-1
32
32
8
8
S81F
S79F, K137N
-
S1D3 2000 C 4 8-8-8-1-17-1-18 4 2 0.5 0.25 - K137N I460V

aMLST, multilocus sequence typing. Number refers to allelle of aroE, gdh, gki, recP, spi, xpt, and ddiA genes, respectively.

bCIP, ciprofloxacin; LVX, levofloxacin; GAT, gatifloxacin; MO, moxifloxacin.

cNo strains had mutations in GyrB sequence.

dS. pneumoniae numbering.

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