Volume 10, Number 7—July 2004
Research
Fluoroquinolone and Other Antimicrobial Resistance in Invasive Pneumococci, Hong Kong, 1995–2001
Pak-Leung Ho*
, Tak-Lun Que†, Susan S. Chiu*, Raymond W. H. Yung†, Tak-Keung Ng§, Dominic N. C. Tsang¶, Wing-Hong Seto*, and Yu-Lung Lau*
, Tak-Lun Que†, Susan S. Chiu*, Raymond W. H. Yung†, Tak-Keung Ng§, Dominic N. C. Tsang¶, Wing-Hong Seto*, and Yu-Lung Lau*Table 3
Characteristics of 11 strains of Streptococcus pneumoniae with reduced susceptibility to ciprofloxacin
| Strain |
Y |
Source |
Serotypea |
MLST profile |
MIC (μg/mL) |
Mutation in QRDR ofcd |
|||||
| CIP |
LVX |
GAT |
MO |
GyrA |
ParC |
ParE |
|||||
| S3F7 |
1996 |
A |
23F |
4-4-2-4-4-1-1 |
32 |
32 |
2 |
1 |
S81F |
K137N |
E474K, I460V |
| S2H9 |
1997 |
A |
23F |
4-4-2-4-4-1-1 |
32 |
32 |
4 |
2 |
S81Y |
K137N |
D435N, I460V |
| S1B7 |
1999 |
B |
23F |
4-4-2-4-4-1-1 |
32 |
32 |
8 |
4 |
S81F |
S79F, K137N |
I460V |
| S1B9 |
1999 |
B |
23F |
4-4-2-4-4-1-1 |
32 |
32 |
16 |
4 |
S81F |
S79F, K137N |
I460V |
| S1D5 |
1999 |
C |
19F |
4-4-2-4-4-1-1 |
32 |
32 |
8 |
4 |
S81F |
S79F, K137N |
I460V |
| S2D6 |
1999 |
A |
14 |
4-4-2-4-4-1-1 |
32 |
32 |
8 |
4 |
S81F |
S79F, K137N |
I460V |
| S1D2 |
2000 |
C |
19F |
4-4-2-4-4-1-1 |
32 |
32 |
8 |
8 |
S81F |
S79F, K137N |
- |
| S1D3 | 2000 | C | 4 | 8-8-8-1-17-1-18 | 4 | 2 | 0.5 | 0.25 | - | K137N | I460V |
aMLST, multilocus sequence typing. Number refers to allelle of aroE, gdh, gki, recP, spi, xpt, and ddiA genes, respectively.
bCIP, ciprofloxacin; LVX, levofloxacin; GAT, gatifloxacin; MO, moxifloxacin.
cNo strains had mutations in GyrB sequence.
dS. pneumoniae numbering.
