Volume 10, Number 7—July 2004
Dispatch
Human Metapneumovirus and Severity of Respiratory Syncytial Virus Disease
Isaac Lazar*, Carla Weibel*, James Dziura*, David Ferguson*, Marie L. Landry*, and Jeffrey S. Kahn*
Table
Comparison between the group of children admitted to PICU with severe RSV disease and the group of children with mild RSV disease
| Characteristic | PICUa | Non PICUa | Statistical comparison (p value)b |
|---|---|---|---|
| Median age (range) |
7 wk (2 wk–21 mo) |
54 wk (10 d–4 y) |
0.025b |
| Prematurity (%) |
5/23 (21.7) |
3/23 (13.0) |
> 0.1c |
| RSVd PCR/DFAe (%) |
21/23 (91.3) |
23/23 (100) |
0.244c |
| Hospitalized (%) |
23/23 (100) |
8/23 (34.8) |
0.004c |
| Median CSSf (range) |
5 (3–6) |
1 (0–4) |
< 0.001b |
| PPVg (%) |
17/23 (73.9) |
0/23 (0) |
NDh |
| RSV/HMPVi co-infection | 0/23 (0) | 0/23 (0) | 1.0 |
aPICU, Pediatric Intensive Care Unit.
cWilcoxon rank sum test.
bχ2 test.
dRSV, respiratory syncytial virus.
eDFA, direct fluorescent antibody screen.
fCCS, clinical severity score.
gPPV, positive pressure ventilation.
hND, non-comparable as patients requiring PPV are admitted to the PICU.
iHMPV, human metapneumovirus.
