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Volume 10, Number 9—September 2004

Research

Viral Loads in Clinical Specimens and SARS Manifestations

I.F.N. Hung*, V.C.C. Cheng*, A.K.L. Wu†, B.S.F. Tang*, K.H. Chan*, C.M. Chu‡, M.M.L. Wong§, W.T. Hui*, L.L.M. Poon*, D.M.W. Tse§, K.S. Chan‡, P.C.Y. Woo*, S.K.P. Lau*, J.S.M. Peiris*, and K.Y. Yuen*Comments to Author 
Author affiliations: *Queen Mary Hospital at the University of Hong Kong, Hong Kong Special Administrative Region (SAR), People’s Republic of China; †Prince of Wales Hospital, Hong Kong SAR, People’s Republic of China; ‡United Christian Hospital, Hong Kong SAR, People’s Republic of China; §Caritas Medical Centre, Hong Kong SAR, People’s Republic of China

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Table 2

SARS-CoV and viral load in different clinical specimens taken during days 10 to 15 after the onset of symptomsa

Clinical specimens Mean viral load in log10 copies/mL (SD), all specimens Mean viral load in log10 copies/mL (SD), positive specimens only Positivity by RT-qPCR (%)
NPA (n = 142) 2.4 (3.1) 5.8 (1.7) 60/142 (42.3)
Serum (n = 53) 1.1 (1.4) 2.7 (0.6) 22/53 (41.5)
Stool (n = 94) 6.1 (3.0) 7.0 (2.1) 82/94 (87.2)
Urine (n = 111) 1.3 (2.1) 4.4 (1.3) 32/111 (28.8)

aSARS-CoV, severe acute respiratory syndrome–associated coronavirus; SD, standard deviation; RT-qPCR, quantitative reverse transcription–polymerase chain reaction; NPA, nasopharyngeal aspirates.

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