Appendix. Figure. Comparison of the predicted amino acid sequences of human parechovirus (HPeV)-3 Canadian isolates no. 81235, 81554, and 82853 with reference sequences of HPeV-1, -2 and -3 (GenBank accession no. S45208, AF055846, and AB084913, respectively) for the VP0-VP3-VP1 proteins (8,10). Asterisks denote identical residues in all strains, whereas shaded amino acids highlight changes between HPeV-3 isolates. The RGD motif present only in HPeV-1 and -2 strains is underlined. The HPeV-1 immunodominant epitope described by Joki-Korpela et al. (15) is shown in bold.