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Volume 11, Number 4—April 2005

Research

Experimental Infection of Prairie Dogs with Monkeypox Virus

Shu-Yuan Xiao*, Elena Sbrana*, Douglas M. Watts*, Marina Siirin*, Amelia P.A. Travassos da Rosa*, and Robert B. Tesh*Comments to Author 
Author affiliations: *University of Texas Medical Branch, Galveston, Texas, USA

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Figure 3

Bronchus from animal MPX-9, which was infected intranasally. A) Cross-section of a bronchus, showing focal metaplasia and proliferation (between the arrows) of the luminal epithelium. B) Higher magnification showing the details of the metaplastic epithelium, accompanied by focal necrosis. Compare to the adjacent unaffected area, which is lined by normal ciliated columnar epithelial cells. C and D) Immunohistochemical staining of the corresponding field shows presence of viral antigen limited to

Figure 3. Bronchus from animal MPX-9, which was infected intranasally. A) Cross-section of a bronchus, showing focal metaplasia and proliferation (between the arrows) of the luminal epithelium. B) Higher magnification showing the details of the metaplastic epithelium, accompanied by focal necrosis. Compare to the adjacent unaffected area, which is lined by normal ciliated columnar epithelial cells. C and D) Immunohistochemical staining of the corresponding field shows presence of viral antigen limited to the region of epithelial abnormality. A and B, hematoxylin and eosin stain; C and D, immunoperoxidase staining with vaccinia antibody. Original magnification: A and C, 4× objectives; B and D, 20× objectives.

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