Volume 11, Number 4—April 2005
Research
Experimental Infection of Prairie Dogs with Monkeypox Virus
Shu-Yuan Xiao*, Elena Sbrana*, Douglas M. Watts*, Marina Siirin*, Amelia P.A. Travassos da Rosa*, and Robert B. Tesh*
Table 1
Results of virus titration of serial blood and throat swab samples taken from prairie dogs after experimental monkeypox infection
| Day after infection | Animal no.* |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MPX-1 |
MPX-3 |
MPX-4 |
MPX-5 |
MPX-6 |
MPX-7 |
MPX-8 |
MPX-9 |
|||||||||
| B | TS | B | TS | B | TS | B | TS | B | TS | B | TS | B | TS | B | TS | |
| 1 | 0 | NT | 0 | NT | 0 | NT | 0 | NT | 0 | NT | 0 | NT | 0 | NT | 0 | NT |
| 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.7 | 0 | 0 | 0 | 0 | 0 | 1.0 | 0 | 0 |
| 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.7 | 0 | 0 | 0 | 2.4 | 0 | 0.7 | 0 | 1.6 |
| 5 | 0 | 0 | 0.7 | 0.7 | 1.9 | 1.9 | 0 | 2.2 | 0 | 0 | 0 | 2.6 | 0 | 1.5 | 0 | 1.7 |
| 6 | 1.2† | 1.4 | 1.7 | 1.5 | 3.9 | 3.2 | 0 | 3.2 | 0 | 2.4 | 0 | 1.4 | 0 | 1.2 | 0 | 1.4 |
| 7 | 2.4 | 3.0 | 2.3 | 2.5 | 5.4 | 4.2 | 0 | 3.6 | 0 | 1.9 | 0 | 2.7 | 0 | 2.0 | 0 | 2.0 |
| 8 | 2.5 | 3.2 | 3.5 | 1.7 | D | D | 0 | 3.6 | 0 | 1.6 | 0 | 2.7 | 0 | 2.3 | 1.5 | 3.2 |
| 9 | 4.0 | 4.3 | D | D | 1.4 | 4.6 | 1.6 | 2.7 | 1.4 | 2.6 | 3.4 | 3.5 | 1.2 | 4.5 | ||
| 10 | 5.3 | 5.1 | 1.0 | 4.8 | 3.5 | 3.0 | 2.1 | 3.7 | 4.4 | 2.5 | 3.6 | 5.0 | ||||
| 11 | D | D | 1.4 | 5.0 | D | D | 1.9 | 3.9 | 4.0 | 4.4 | 3.8 | 5.1 | ||||
| 12 | 1.2 | 5.1 | 2.3 | 4.7 | 4.4 | 4.7 | 4.3 | 5.2 | ||||||||
| 13 | 2.4 | 5.1 | 2.0 | 3.5 | 4.0 | 5.1 | D | D | ||||||||
| 14 | NT | NT | D | D | NT | NT | ||||||||||
| 15 | 4.5 | 4.4 | 4.0 | 5.0 | ||||||||||||
| 16 | NT | 4.3 | NT | 5.0 | ||||||||||||
| 17 | NT | 3.2 | NT | 5.2 | ||||||||||||
| 18 | NT | 2.1 | NT | 5.0 | ||||||||||||
| 19 | NT | 2.9 | NT | 4.8 | ||||||||||||
| 20 | NT | 1.7 | NT | 4.2 | ||||||||||||
| 21 | NT | 1.0 | NT | 4.0 | ||||||||||||
| 22 | NT | 0 | NT | 2.9 | ||||||||||||
*Animals MPX-1, MPX-3, and MPX-4 were infected intraperitoneally; animals MPX-5 to MPX-9 were infected intranasally.
†Indicates titer of monkeypox virus in sample; log10 PFU/mL of sample (blood [B] or throat swab diluent [TS]); 0, <100.7 PFU/mL; NT, not tested; D, animal dead.
