Major Outbreak of Hepatitis A Associated with Orange Juice among Tourists, Egypt, 2004
Christina Frank* , Jan Walter*, Marion Muehlen*, Andreas Jansen*, Ulrich van Treeck†, Anja M. Hauri‡, Iris Zoellner§, Magda Rakha¶, Marina Hoehne*, Osamah Hamouda*, Eckart Schreier*, and Klaus Stark*
Author affiliations: *Robert Koch Institute, Berlin, Germany; †Institute of Public Health, State of North-Rhine Westphalia, Münster, Germany; ‡Hesse State Health Office, State of Hesse, Dillenburg, Germany; §State Health Authority, State of Baden-Wuerttemberg, Stuttgart, Germany;; ¶Ministry of Health and Population, Cairo, Egypt;
Figure 3. Phylogenetic analysis of the VP1–2A junction region. The sequence of a 160-bp-long PCR fragment (isolate Egy/1/05/DEU, GenBank accession no. AY741663) of the hepatitis A VP1 region was compared to published reference sequences of hepatis A virus. Genotype Ia: GenBank accession nos. AJ306374(Arg-1), AY656712 (BAV/2/03/DEU*), AY028976 (SA/10/2000/DEU), AY046073 (Datteln/01/DEU), and AY747173 (NRW/3/04/DEU*). Genotype Ib: L07728 (Jor 88), M14707 (HM-175). The scale represents nucleotide substitutions per position (* denotes previous German outbreak-causing strains).
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