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Volume 13, Number 1—January 2007


Alkhurma Hemorrhagic Fever Virus in Ornithodoros savignyi Ticks

Rémi N. Charrel*Comments to Author , Shamsudeen Fagbo†, Gregory Moureau*, Mohammad Hussain Alqahtani†, Sarah Temmam*, and Xavier de Lamballerie*
Author affiliations: *Université de la Méditerranée, Marseille, France; †King Abdul Aziz University, Jeddah, Saudi Arabia;

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Table 2

Genetic differences between Alkhurma hemorrhagic fever virus coding sequences of human (strain 1176 AF331718) and tick (strain JE7, DQ154114) origin*

GeneNo. mutated sites/no. sites in gene (%)
Synonymous mutationsNonsynonymous mutations
VirC2/291 (0.69)
CTHD1/60 (1.67)
prM2/267 (0.75)
M4/225 (1.78)1/225 (0.45)0.20
E6/1,488 (0.41)2/1488 (0.13)0.25
NS14/1,062 (0.32)3/1,062 (0.28)0.43
NS2a8/687 (1.16)1/687 (0.15)0.11
NS2b2/393 (0.51)3/393 (0.76)0.60
NS39/1,863 (0.48)5/1,863 (0.27)0.36
NS4a2/378 (0.53)2/378 (0.53)0.50
2K1/69 (1.45)
NS4b4/756 (0.53)4/756 (0.53)0.50
NS510/2,709 (0.37)3/2,709 (0.15)0.11

*Ka:Ks, ratio of nonsynonymous-to-synonymous nucleotides; VirC; mature virion C protein; CTHD, C-terminal hydrophobic domain; prM, premembrane; M, membrane; E, envelope; NS, nonstructural; 2K, transmembrane domain.

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