Volume 13, Number 10—October 2007
THEME ISSUE
Global Poverty and Human Development
Research
Cost-effectiveness of Algorithms for Confirmation Test of Human African Trypanosomiasis
Pascal Lutumba*†, Filip Meheus‡, Jo Robays†, Constantin Miaka*, Victor Kande*, Philippe Büscher†, Bruno Dujardin§, and Marleen Boelaert†
Table 2
Probabilities used in baseline scenario and plausible range*
| Characteristic | Baseline value, % | Reference | Plausible range, % | Reference |
|---|---|---|---|---|
| HAT prevalence | 1.0 | Annual reports PNLTHA (1995–2002) | 0.5–5.0 | Annual reports PNLTHA (1995-2002) |
| LNP sensitivity | 18.8 | (20) | 18.8–58.6 | (3,4) |
| LNP specificity | 100.0 | By convention | NA | |
| FBE sensitivity | 3.9 | (4) | 3.9–22.4 | (3,4) |
| FBE specificity | 100.0 | By convention | NA | |
| TBF sensitivity | 27.3 | (4) | 27.3–34.5 | (3,4) |
| TBF specificity | 100.0 | By convention | NA | |
| CTC sensitivity | 56.5 | (4) | 29.0–73.0 | (3,7) |
| CTC specificity | 100.0 | By convention | NA | |
| mAECT sensitivity | 75.3 | (4) | 43.0–88.0 | (3,7) |
| mAECT specificity | 100.0 | By convention | NA | |
| CATT whole blood sensitivity | 90.4 | (23) | 68.8–99.2 | (21–24); John M (unpub. data) |
| CATT whole blood specificity | 96.5 | (23) | 83.5–98.4 | (21,23,24) |
| CATT titration sensitivity† | 78.8 | (4) | 78.8–100.0 | In absence of data in literature, we considered the maximum of 100% |
| CATT titration specificity† | 59.0 | (4) | 59.0–100.0 | In absence of data in literature, we considered the maximum of 100% |
| Pentamidine efficacy | 98.0 | ‡ | 98.0–99.0 | (25) |
| Melarsoprol efficacy | 90.0 | ‡ | 70.0–96.3 | (25,26) |
| Latrogenic mortality of pentamidine | 0.1 | ‡ | 0.1–0.7 | (25) |
| Latrogenic mortality of melarsoprol | 2.0 | 2.0–7.0 | (25–27) |
*HAT, human African trypanosomiasis; PNLTHA, Programme National de lutte contre la Trypanosomiase Humaine Africaine; LNP, lymph node puncture; NA, not applicable; FBE, fresh blood examination; TBF, thick blood film; CTC, capillary tube centrifugation; mAECT, mini-anion exchange centrifugation technique; CATT, card agglutination test for trypanosomiasis.
†Conditional values to CATT whole blood positive. The plausible range included the value at different end-titers (4, 16, 32).
‡Data extracted from PNLTHA/RDC annual report 1999.
