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Volume 13, Number 11—November 2007
Dispatch

Human Multidrug-Resistant Salmonella Newport Infections, Wisconsin, 2003–2005

Amy E. Karon*1Comments to Author , John R. Archer†, Mark J. Sotir*†1, Timothy A. Monson‡, and James J. Kazmierczak*†
Author affiliations: *University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA; †Wisconsin Division of Public Health, Madison, Wisconsin, USA; ‡Wisconsin State Laboratory of Hygiene, Madison, Wisconsin, USA;

Main Article

Table 1

Antimicrobial drug resistance patterns of human Salmonella Newport isolates among case-patients*

Resistant to Frequency (%)
Wisconsin (n = 268), 2003–2005 Rest of United States (n = 402), 2003–2004
None detected 95 (35) 317 (79)
>1 CLSI subclass† 173 (65) 85 (21)
>2 CLSI subclasses 150 (56) 81 (20)
>3 CLSI subclasses 150 (56) 77 (19)
>4 CLSI subclasses 150 (56) 74 (18)
>5 CLSI subclasses 146 (55) 71 (18)
At least ACSSuT‡ 139 (52) 69 (17)
At least ACSuTm§ 7 (3) 4 (1)
At least MDRAmpC¶ 137 (51) 68 (17)
Quinolone and cephalosporin (third generation)# 5 (2)** 2 (0.5)

*Based on data from the National Antimicrobial Resistance Monitoring System for Enteric Bacteria.
†CLSI, Clinical and Laboratory Standards Institute. Subclasses included aminoglycosides (kanamycin, gentamicin, streptomycin), aminopenicillins (ampicillin), β-lactamase inhibitor combinations (amoxicillin-clavulanic acid), first-generation cephalosporins (cephalothin), third-generation cephalosporins (ceftriaxone), cephamycins (cefoxitin), folate pathway inhibitors (trimethoprim-sulfamethoxazole), phenicols (chloramphenicol), quinolones (nalidixic acid, ciprofloxacin), sulfonamides (sulfisoxazole), and tetracyclines (tetracycline).
‡ACSSuT, ampicillin, chloramphenicol, streptomycin, sulfamethoxazole/sulfisoxazole, tetracycline.
§ACSuTm, ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole.
¶At least drugs to which MDRAmpC is resistant: chloramphenicol, streptomycin, trimethoprim-sulfamethoxazole, sulfisoxazole, tetracycline, amoxicillin-clavulanic acid, ampicillin, cefoxitin, cephalothin, and ceftriaxone. Note: the Wisconsin State Laboratory of Hygiene does not routinely test Salmonella isolates for resistance to ceftiofur, a third-generation cephalosporin that is related to ceftriaxone.
#Resistant to ciprofloxacin and/or nalidixic acid, and ceftriaxone.
**1 isolate in this category was also MDRAmpC.

Main Article

1Current affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Page created: July 04, 2010
Page updated: July 04, 2010
Page reviewed: July 04, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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