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Volume 13, Number 11—November 2007

Research

Human Salmonella and Concurrent Decreased Susceptibility to Quinolones and Extended-Spectrum Cephalosporins

Jean M. Whichard*Comments to Author , Kathryn Gay*1, Jennifer E. Stevenson*2, Kevin J. Joyce*, Kara L. Cooper*, Michael Omondi*, Felicita Medalla*, George A. Jacoby†, and Timothy J. Barrett*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Lahey Clinic, Burlington, Massachusetts, USA;

Main Article

Table 4

Resistance mechanisms among NARMS non-Typhi Salmonella with decreased susceptibility to quinolones and extended-spectrum cephalosporins, United States, 1996–2004*

Isolate gyrA codon 83 change gyrA codon 87 change parC codon 57 change parC codon 80 change β-Lactamase isoelectric points β-Lactamase genes
AM18280 S83Y WT T57S WT >8.4 blaCMY-2
AM09124 S83F WT WT WT ND ND
AM15266 WT D87Y WT WT ND ND
AM12389 S83Y WT WT WT ND ND
AM15010 WT WT T57S WT 7.0, 7.6† blaSHV-30
AM03005 S83Y D87G T57S WT ND ND
AM15201 S83F WT T57S WT >8.4 blaCMY-2
AM21465 S83F WT T57S WT >8.4 blaCMY-2
AM20428 S83F WT WT WT 5.4 blaTEM-1b
AM06960 S83Y D87G T57S S80I 7.4 blaOXA-1
AM08081 S83Y D87G T57S S80I 7.4 blaOXA-1
AM08208 S83Y D87G T57S S80I 7.4 blaOXA-1
AM09864 S83Y D87G T57S S80I 5.3, 6.9, 8.0 blaTEM-1, blaOXA-9, blaSHV-12
AM11007 S83Y D87G T57S S80I 7.4 blaOXA-1
AM14058 S83Y D87G T57S S80I 5.4, >8.4 blaTEM-1b, blaCMY-23
AM16094 S83Y D87G T57S S80I 7.4 blaOXA-1
AM18622 S83Y D87G T57S S80I 7.4, 7.8 blaOXA-1
AM19422 S83Y D87G T57S S80I 7.4 blaOXA-1
AM20227 S83Y D87G T57S S80I 7.4 blaOXA-1
AM20256 S83Y D87G T57S S80I 7.4 blaOXA-1
AM02544 WT D87N WT WT 5.4, 8.0 blaTEM-1, blaOXA-1, blaSHV-12
AM08739 S83Y WT WT WT 5.4, >8.4 blaTEM-1b, blaCMY-2
AM11682 S83F WT WT WT >8.4 blaCMY-2
AM14364 S83Y WT WT WT 5.4, >8.4 blaTEM-1b, blaCMY-2
AM14807 S83Y WT WT WT >8.4 blaCMY-2
AM20205 WT D87N WT WT 5.4 blaTEM-1b
AM19537 S83Y WT T57S WT >8.4 blaCMY-2

*NARMS, National Antimicrobial Resistance Monitoring System; WT, wild type; ND, not determined.
†Gene responsible not yet identified.

Main Article

1Current affiliation: Banfield, The Pet Hospital, Philadelphia, Pennsylvania, USA

2Current affiliation: Washington State University, Pullman, Washington, USA

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