Volume 13, Number 11—November 2007
Dispatch
Viral Load as Predictor of Crimean-Congo Hemorrhagic Fever Outcome
Darja Duh*, Ana Saksida*, Miroslav Petrovec*, Salih Ahmeti†, Iusuf Dedushaj‡, Marcus Panning§, Christian Drosten§, and Tatjana Avšič-Županc*
Table
Detection of CCHF viral load by real-time RT-PCR in serum of patients with acute CCHF, Kosovo*
| Patient no. | Disease severity | Day of illness | IgM titer | IgG titer | Viral load (copies/mL) |
|---|---|---|---|---|---|
| 1 | Fatal | 2 | Neg | Neg | 6.5100 × 108 |
| 2 | Fatal | 3 | Neg | Neg | 2.5040 × 109 |
| 3 | Fatal | 4 | Neg | Neg | 2.7400 × 109 |
| 4 | Fatal | 9 | Neg | Neg | 3.3840 × 109 |
| 5 | Fatal | 4 | 1,600 | Neg | 1.0160 × 108 |
| 6 | Fatal | 6 | 3,200 | Neg | 1.3450 × 1010 |
| 7 | Fatal | 7 | 400 | Neg | 1.8675 × 109 |
| 8 | Fatal | 7 | 800 | Neg | 3.4800 × 109 |
| 9 | Fatal | 7 | 800 | Neg | 1.2920 × 109 |
| 10 | Severe | 8 | >6,400 | Neg | 1.6050 × 106 |
| 18 | >6,400 | 400 | 1.1500 × 105 | ||
| 11 | Severe | 9 | Neg | Neg | 2.3250 × 107 |
| 24 | >6,400 | >6,400 | Neg | ||
| 12 | Severe | 4 | 800 | Neg | 3.3900 × 106 |
| 16 | 6,400 | 3,200 | Neg | ||
| 13 | Severe | 2 | Neg | Neg | 1.0430 × 109 |
| 9 | >6,400 | 400 | 3.1200 × 103 | ||
| 42 | > 6,400 | 3,200 | Neg | ||
| 14 | Severe | 8 | Neg | Neg | 8.1000 × 106 |
| 14 | 6,400 | Neg | 2.0100 × 103 | ||
| 15 | Severe | 3 | Neg | Neg | 3.8100 × 107 |
| 14 | 6,400 | 200 | Neg | ||
| 16 | Severe | 3 | >1,600 | Neg | 2.5235 × 106 |
| 6 | >800 | >800 | 2.2350 × 104 | ||
| 17 | Severe | 4 | Neg | Neg | 3.3600 × 107 |
| 10 | >6,400 | 100 | 3.8100 × 104 | ||
| 18 | Severe | 2 | Neg | Neg | 7.8500 × 107 |
| 9 | 6,400 | 400 | 3.2000 × 103 | ||
| 23 | >6,400 | >6,400 | Neg | ||
| 19 | Moderate | 12 | >6,400 | Neg | 5.7525 × 104 |
| 17 | >6,400 | 800 | Neg | ||
| 20 | Moderate | 9 | >6,400 | 1,600 | 1.9600 × 103 |
| 11 | >6,400 | 3,200 | Neg | ||
| 21 | Moderate | 12 | >6,400 | 800 | 1.9191 × 105 |
| 13 | >6,400 | 3,200 | 1.0240 × 104 | ||
| 32 | >6,400 | >6,400 | Neg | ||
| 22 | Moderate | 10 | >6,400 | Neg | 4.6400 × 104 |
| 19 | >6,400 | >6,400 | 1.2000 × 103 | ||
| 26 | >6,400 | >6,400 | Neg | ||
| 23 | Moderate | 9 | 6,400 | 6,400 | 7.6800 × 103 |
| 20 | >6,400 | >6,400 | 7.5000 × 102 | ||
| 24 | Moderate | 7 | 400 | Neg | 7.4400 × 105 |
| 18 | >6,400 | 6,400 | Neg |
*CCHF, Crimean-Congo hemorrhagic fever: RT-PCR, reverse transcription–PCR; Ig, immunoglobulin; neg, negative result.
