Epidemiologic and Virologic Investigation of Hand, Foot, and Mouth Disease, Southern Vietnam, 2005
Phan Van Tu*, Nguyen Thi Thanh Thao*, David Perera†, Khanh Huu Truong‡, Nguyen Thi Kim Tien*, Tang Chi Thuong‡, Ooi Mong How§, Mary Jane Cardosa†, and Peter Charles McMinn¶
Author affiliations: *Pasteur Institute, Ho Chi Minh City, Vietnam; †Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia; ‡Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; §Sibu General Hospital, Sibu, Sarawak, Malaysia; ¶University of Sydney, Sydney, New South Wales, Australia;
Figure 3. Monthly distribution of 387 cases of hand, foot, and mouth disease (HFMD) associated with isolation of either coxsackievirus A16 (CVA16) (214 cases) or human enterovirus 71 (HEV71) (173 cases), southern Vietnam, 2005. RNA was extracted from cells inoculated with vesicle, throat swab, or stool specimens. Partial VP4 gene sequences were amplified by reverse transcription–PCR (RT-PCR) by using specific primers (22), the amplified cDNA sequenced, and the serotype and/or genogroup specificity determined by BLAST analysis. A) Monthly distribution of CVA16 and HEV71-associated HFMD cases. B) Monthly distribution of 173 HFMD cases associated with HEV71 infection with strains belonging to subgenogroups C1, C4, or C5.
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