Volume 13, Number 11—November 2007
Synopsis
Literature Review and Case Histories of Histoplasma capsulatum var. duboisii Infections in HIV-infected Patients
Pierre Loulergue*†, Frédéric Bastides‡, Véronique Baudouin§, Jacques Chandenier‡, Patricia Mariani-Kurkdjian§, Bertrand Dupont*†, Jean-Paul Viard*†, Françoise Dromer¶, and Olivier Lortholary†¶
Table 2
Comparison of clinical and microbiologic findings of HIV-infected and immunocompetent patients with histoplasmosis due to variety duboisii*†
| Characteristic | HIV positive (n = 17) | HIV negative (n = 20) |
|---|---|---|
| Age, y (range) | 35 (2–65) | 34 (8–62) |
| Sex (M:F) |
12:5 |
19:1 |
| Visceral localizations | ||
| Lymph nodes | 53 | 65 |
| Skin | 59 | 40 |
| Bones | 18 | 25 |
| Lungs | 0† | 35† |
| Gastrointestinal | 12 | 5 |
| Disseminated |
85† |
55† |
| Clinical manifestations | ||
| Fever | 58† | 15† |
| Weight loss, asthenia, anorexia | 54 | 30 |
| Respiratory symptoms | 0 | 20 |
| Hepatosplenomegaly |
12 |
15 |
| Diagnosis sites | ||
| Lymph nodes | 24 | 45 |
| Skin | 48 | 35 |
| Bone marrow | 18 | 0 |
| Bone | 12 | 5 |
| Gastrointestinal | 6 | 5 |
| Pus | 6 | 25 |
| Lung |
0† |
25† |
| Mycologic diagnosis | ||
| Direct examination | 100 | 40 |
| Culture | 64 | 65 |
| Blood culture |
12 |
0 |
| Treatment | ||
| Amphotericin B | 66 | 80 |
| Ketoconazole | 12 | 35 |
| Itraconazole | 64 | 20 |
| Fluconazole |
12 |
0 |
| Outcome | ||
| Relapse | 12 | 40 |
| Death | 24 | 5 |
*Except where indicated, all values are percentages. HIV-negative patients are from Dupont et al. (13).
†p<0.05.
