Susceptibility of Canada Geese (Branta canadensis) to Highly Pathogenic Avian Influenza Virus (H5N1)
John Pasick* , Yohannes Berhane*, Carissa Embury-Hyatt*, John Copps*, Helen Kehler*, Katherine Handel*, Shawn Babiuk*, Kathleen Hooper-McGrevy*, Yan Li†, Quynh Mai Le‡, and Song Lien Phuong§
Author affiliations: *Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada; †Public Health Agency of Canada, Winnipeg, Manitoba, Canada; ‡National Institute of Hygiene and Epidemiology, Hanoi, Vietnam; §National Center for Veterinary Diagnosis, Hanoi, Vietnam;
Figure 1. Immunohistochemical staining for influenza virus nucleoprotein in central and peripheral nervous system of naive juvenile Canada geese tissues after challenge with influenza virus (H5N1). A) Cerebrum. Positive immunolabeling of neurons, glial cells, ependymal and choroid plexus epithelial cells. B) Cerebellum. Extensive positive immunolabeling of Purkinje cells and neurons of the granular layer. C) Spinal cord. Positive immunolabeling of ependymal cells of the central canal and adjacent neurons and glial cells. D) Small intestine. Positive immunolabeling of neurons of the submucosal plexus.
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