Emerging Infectious Disease ISSN: 1080-6059

Susceptibility of Canada Geese (Branta canadensis) to Highly Pathogenic Avian Influenza Virus (H5N1)

John Pasick*

, Yohannes Berhane*, Carissa Embury-Hyatt*, John Copps*, Helen Kehler*, Katherine Handel*, Shawn Babiuk*, Kathleen Hooper-McGrevy*, Yan Li†, Quynh Mai Le‡, and Song Lien Phuong§

Author affiliations: *Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada; †Public Health Agency of Canada, Winnipeg, Manitoba, Canada; ‡National Institute of Hygiene and Epidemiology, Hanoi, Vietnam; §National Center for Veterinary Diagnosis, Hanoi, Vietnam;

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Figure 2

Immunohistochemical (IHC) staining for influenza virus nucleoprotein in tissues of naïve juvenile Canada geese after challenge with influenza virus (H5N1). A) Pancreas. Large areas of necrosis are surrounded by pancreatic acinar cells with strong positive intranuclear and intracytoplasmic immunolabeling. B) Heart. Positive intranuclear and intracytoplasmic immunolabeling of myocytes. C) Proventriculus. Strong positive immunolabeling of compound tubular gland epithelium. D) Splenic arteriole. Positive IHC staining of vascular smooth muscle cells.

Figure 2. Immunohistochemical (IHC) staining for influenza virus nucleoprotein in tissues of naïve juvenile Canada geese after challenge with influenza virus (H5N1). A) Pancreas. Large areas of necrosis are surrounded by pancreatic acinar cells with strong positive intranuclear and intracytoplasmic immunolabeling. B) Heart. Positive intranuclear and intracytoplasmic immunolabeling of myocytes. C) Proventriculus. Strong positive immunolabeling of compound tubular gland epithelium. D) Splenic arteriole. Positive IHC staining of vascular smooth muscle cells.

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