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Volume 13, Number 12—December 2007

Research

Susceptibility of Canada Geese (Branta canadensis) to Highly Pathogenic Avian Influenza Virus (H5N1)

John Pasick*Comments to Author , Yohannes Berhane*, Carissa Embury-Hyatt*, John Copps*, Helen Kehler*, Katherine Handel*, Shawn Babiuk*, Kathleen Hooper-McGrevy*, Yan Li†, Quynh Mai Le‡, and Song Lien Phuong§
Author affiliations: *Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada; †Public Health Agency of Canada, Winnipeg, Manitoba, Canada; ‡National Institute of Hygiene and Epidemiology, Hanoi, Vietnam; §National Center for Veterinary Diagnosis, Hanoi, Vietnam;

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Table 2

Distribution of influenza virus antigen in tissues of naïve juvenile Canada geese tissues after challenge with influenza virus (H5N1)

Tissue Animal 861S/36R
dpi 3* Animal 855S/30R
dpi 4* Animal 851S/26R
dpi 5* Animal 854S/29R
dpi 5* Animal 860S/35R
dpi 5* IHC-positive cell types
Trachea + + Vascular endothelium
Lung ++ ++ + Vascular endothelium, mononuclear cells
Esophagus ++ ++ + + Epithelium, Vascular smooth muscle, Smooth muscle of muscularis externa, Mucous glands
Proventriculus + + ++ Epithelium (columnar, glandular), muscularis mucosa, vascular smooth muscle, parasympathetic ganglia
Ventriculus ++ ++ ++ Epithelium
Gut ++ +++ ++ + Parasympathetic ganglia, mucosal smooth muscle, vascular endothelium
Cecal tonsil ++ ++ + ++ Parasympathetic ganglia
Pancreas ++ +++ ++ ++ + Exocrine acinar cells
Liver + Hepatocytes
Spleen ++ + Vascular smooth muscle, mononuclear cells
Kidney + Tubular epithelium
Muscle + + Vascular smooth muscle
Heart ++ ++ ++ + + Myocytes
Brain ++ +++ +++ +++ +++ Neurons, glial cells, ependymal cells, choroid plexus epithelium
Spinal cord + ++ ++ ++ ++ Ependymal cells, neurons, glial cells, leptomeninges
Sciatic nerve + Vascular endothelium
Brachial nerve None

*Numbers of immunohistochemically positive cells: +, few; ++, moderate; +++, numerous; –, virus antigen negative; dpi, days postinfection.

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