Emerging Infectious Disease ISSN: 1080-6059

Worldwide Emergence of Extensively Drug-resistant Tuberculosis

N. Sarita Shah*¹

, Abigail Wright†, Gill-Han Bai‡², Lucia Barrera§², Fadila Boulahbal¶², Nuria Martín-Casabona#², Francis Drobniewski**², Chris Gilpin††², Marta Havelková‡‡², Rosario Lepe§§², Richard Lumb¶¶², Beverly Metchock*², Françoise Portaels##², Maria Filomena Rodrigues***², Sabine Rüsch-Gerdes†††², Armand Van Deun##², Veronique Vincent‡‡‡², Kayla Laserson*, Charles Wells*, and J. Peter Cegielski*

Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †World Health Organization, Geneva, Switzerland; ‡Korean Institute of Tuberculosis, Seoul, Republic of Korea; §National Institute of Infectious Diseases, Buenos Aires, Argentina; ¶Institut Pasteur d’Algérie, Alger, Algeria; #Hospital Universitaris Vall d’Hebron, Barcelona, Spain; **Health Protection Agency, London, United Kingdom; ††Prince Charles Hospital, Brisbane, Queensland, Australia; ‡‡National Institute of Public Health, Scrobarova, Czech Republic; §§Institute of Public Health of Chile, Providencia Santiago, Chile; ¶¶Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; ##Institute of Tropical Medicine, Antwerp, Belgium; ***National Institute of Health, Porto, Portugal; †††National Reference Center for Mycobacteria, Borstel, Germany; ‡‡‡Institut Pasteur, Paris, France; 1Current affiliation: Albert Einstein College of Medicine, Bronx, New York, USA; 2Member: World Health Organization/International Union against Tuberculosis and Lung Diseases Network of Supranational Reference Laboratories

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Figure 2

Selection of study sample and summary of drug-resistance patterns of isolates. SRL, Supranational Reference Laboratory. *Tested before 2000 or after 2004 (n = 247) or tested for resistance to <3 classes of second-line drugs (n = 535). †Data for ethambutol resistance missing for 5 isolates.

Figure 2. Selection of study sample and summary of drug-resistance patterns of isolates. SRL, Supranational Reference Laboratory. *Tested before 2000 or after 2004 (n = 247) or tested for resistance to <3 classes of second-line drugs (n = 535). †Data for ethambutol resistance missing for 5 isolates.

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