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Volume 13, Number 4—April 2007


Global Distribution of Panton-Valentine Leukocidin–positive Methicillin-resistant Staphylococcus aureus, 2006

Anne Tristan*†Comments to Author , Michele Bes*, Helene Meugnier*, Gerard Lina*, Bülent Bozdogan†, Patrice Courvalin†, Marie-Elisabeth Reverdy*, Mark C. Enright‡, François Vandenesch*, and Jerome Etienne*
Author affiliations: *INSERM, Lyon, France; †Unité des Agents Antibactériens, Centre National de Référence des Antibiotiques, Institut Pasteur, Paris; ‡Imperial College London, London, England, United Kingdom;

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Table 2

Toxin gene content of PVL-positive community-acquired methicillin-resistant Staphylococcus aureus clones*

agr type ST No. (%) Toxin genes always 
detected (100%) Toxin genes sometimes detected (%)
agr1 46 (9.8)
ST8 25 (54.3) lukPV, lukDE hlgv (95.8), sek (91.7), sed (16.7), seb (4.2), hlB (4.2)
ST59 7 (15.2) lukPV, hlgv hlB (87.5), sek (87.5), seb (62.5), lukDE (12.5)
ST22 3 (6.5) sem, seo, lukPV, hlg
ST766 1 (2.2) sem, seo, lukPV, hlg
ST 377 10 (21.7) lukPV, edinA/B/C, hlB, hlg
agr2 9 (1.9)
ST5 9 (100) sem, seo, lukPV, lukED, hlgv edinA/B/C (55.5)
agr3 414 (88.3)
ST80 357 (83.2) etd, lukPV, edinA/B/C lukDE (99.7), hlgv (99.7), hlB (0.8)
ST30 20 (4.8) sem, seo, lukPV, hlg sek (5.0), tst (5.0)
ST37 1 (0.2) sec, sem, seo, tst, lukPV, hlg
ST93 4 (1) lukPV
ST1 32 (7.7) lukPV, seh, lukDE, hlgv sea (78.1), sec (68.7), sek (68.7), seb (25.0), edinA/B/C (3.1)

*PVL, Panton-Valentine leukocidin; ST, sequence type; lukPV, PVL genes; lukDE, LukE–lukD leukocidin genes; gamma (hlg), gamma variant (hlgv), and β (hlb) hemolysin genes; sea to see, seh, sek, sem, seo, staphylococcal enterotoxin type A to E, H, K, M, and O genes, respectively; tst, toxic shock toxin gene; eta, etb, etd: exfoliative toxin type A, B, and D genes, respectively; edinA/B/C, epidermal cell differentiation inhibitor; agr, accessory gene regulator.

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