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Volume 13, Number 5—May 2007

Dispatch

Chikungunya Virus in US Travelers Returning from India, 2006

Robert S. Lanciotti*Comments to Author , Olga L. Kosoy*, Janeen J. Laven*, Amanda J. Panella*, Jason O. Velez*, Amy J. Lambert*, and Grant L. Campbell*
Author affiliations: *Centers for Disease Control and Prevention, Fort Collins, Colorado, USA;

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Table 1

Diagnostic test results for 35 travelers infected with chikungunya virus (CHIKV), 2006*

Sample IgM ELISA† IgG ELISA† PRNT‡ Virus isolation
(Vero cells) RT-PCR§ Viremia, PFU/mL¶ Days from onset of illness
to collection State of US
residence Return date, 2006
1
17.7
3.2
640


NA
0
NJ
10/12
2
1.7
1.7
<10

+
104.0
1
CA
Before 11/28
3
1.2
1.1
ND
+
+
104.1
1
IL
9/29
4
1.8
NS
ND
+
+
106.8
2
CA
Before 9/16
5
1.2
0.76
ND
+
+
105.1
2
MA
9/10
6
1.8
1.6
<10
+
+
106.0
3
PA
Before 8/20
7
1.6
1.2
ND
+
+
105.3
3
CA
10/2
8
NS
1.4
ND

+
103.9
4
WI
10/9
9
22.0
4.3
5,120


NA
4
CA
Before 10/6
10
1.1
0.95
<10

+
104.5
6
CA
Before 8/13
11
7.4
0.96
40


NA
7
CA
Before 9/23
12
15.0
0.60
320


NA
8
CT
Before 7/6
13
26.2
1.2
160
ND

NA
8
DC
Before 10/16
14
12.9
5.8
1,80
ND

NA
10
CA
Before 9/22
15
38.8
2.3
2,560
ND
ND
NA
19
CT
Before 7/6
16
12.7
1.5
640
ND

NA
20
IL
8/23
17
16.9
4.8
640
ND

NA
30
IL
6/25
18
8.3
3.7
640
ND
ND
NA
31
HI
Before 8/2
19
6.6
1.5
640
ND

NA
31
CA
Before 8/13
20
2.6
6.8
320
ND

NA
34
MD
Before 3/20
21
5.0
NS
640
ND

NA
34
IL
Before 9/22
22
15.1
4.1
1,280
ND

NA
38
CA
Before 10/2
23
4.3
5.9
2,560
ND

NA
42
PA
Before 8/20
24
5.6
NS
320
ND

NA
43
Unknown
Unknown
25
3.1
3.7
640
ND

NA
44
IL
Before 9/12
26
26.6
13.4
5,120
ND
ND
NA
48
SC
6/24
27
30.7
6.6
5,120
ND

NA
61
CA
Before 10/26
28
6.1
11.4
2,560
ND

NA
62
CT
Before 10/3
29
9.4
16.0
640
ND

NA
63
CA
8/23
30
7.5
8.4
1,280
ND

NA
71
MN
6/8
31
5.3
5.8
640
ND

NA
71
MN
6/8
32
3.7
16.1
320
ND

NA
75
LA
Before 3/30
33
9.8
10.1
2,560
ND

NA
92
IL
7/9
34
7.5
3.1
160
ND

NA
101
PA
Before 10/13
35 24.6 11.9 20,480 ND NA Unknown IL Before 11/08

*IgM, immunoglobulin M; PRNT, plaque reduction neutralization test; RT-PCR, reverse transcription–PCR; NA, not applicable; ND, not done
(sampled depleted); NS, nonspecific reaction in ELISA.
†Values are patient sample optical densities divided by a negative control optical density; values >3 are positive.
‡Values are 90% plaque reduction neutralization titers.
§Real-time, fluorescence-based assay for detecting CHIKV RNA; positive samples had crossing threshold values <37 with both primer sets.
¶Estimated CHIKV PFU/mL by real-time RT-PCR using a standard curve generated with plaque-titrated/calibrated CHIKV standards.

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