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Volume 13, Number 6—June 2007

Research

Minority-Variant pfcrt K76T Mutations and Chloroquine Resistance, Malawi

Jonathan J. Juliano*, Jesse J. Kwiek*, Kathryn Cappell*, Victor Mwapasa†, and Steven R Meshnick*Comments to Author 
Author affiliations: *University of North Carolina, Chapel Hill, North Carolina, USA; †University of Malawi, Blantyre, Malawi

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Table 2

Sensitivity testing of HTA on mixes of genomic DNA at known concentrations*

Phosphorimager data
% Mutant Average wild-type (%) SD weight Average mutant (%) SD mutant
50 48.1 2.39 51.9 2.39
20 77.0 2.56 23.0 2.55
10 88.9 2.34 11.1 2.34
5 94.8 0.95 5.2 0.95
1 98.7 0.22 1.3 0.22
0.1 100 0 ND ND

*HTA, heteroduplex tracking assay; ND, none detected.

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