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Volume 13, Number 6—June 2007

Research

Minority-Variant pfcrt K76T Mutations and Chloroquine Resistance, Malawi

Jonathan J. Juliano*, Jesse J. Kwiek*, Kathryn Cappell*, Victor Mwapasa†, and Steven R Meshnick*Comments to Author 
Author affiliations: *University of North Carolina, Chapel Hill, North Carolina, USA; †University of Malawi, Blantyre, Malawi

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Table 3

Detection of pfcrt 76T in clinical samples*

Clinical site No. samples No. positive samples by HTA (%) No. positive samples by ARPCR (%) Avg mutant population by HTA (%) SD
MHP 27 1 (3.7)† 0 (0) 3.2 0.07
MM 60 21 (35)† 0 (0) 3.3 1.4

*HTA, heteroduplex tracking assay; ARPCR, standard allele-restricted PCR; MHP, Malaria and HIV in Pregnancy; MM, Mpemba and Madziabango.
†p = 0.001, Fisher exact test.

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