Emerging Infectious Disease ISSN: 1080-6059

Ongoing Genome Reduction in Mycobacterium ulcerans

Simona Rondini*¹, Michael Käser*¹, Timothy Stinear†², Michel Tessier‡, Cyrill Mangold‡, Gregor Dernick‡, Martin Naegeli*, Françoise Portaels§, Ulrich Certa‡, and Gerd Pluschke*

Author affiliations: *Swiss Tropical Institute, Basel, Switzerland; †Institut Pasteur, Paris, France; ‡F. Hoffmann-La Roche Ltd., Basel, Switzerland; §Institute of Tropical Medicine, Antwerp, Belgium; 1These authors contributed equally to this work.; 2Current affiliation: Monash University, Melbourne, Victoria, Australia;

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Figure 4

Positions of overlapping or adjacent plasmid inserts in regions of difference (RDs) 4, 5, and 8. Identical results retrieved by different plasmids with overlapping sequences or sequences in closest proximity demonstrate the reproducibility and reliability of the differential genomic hybridization method.

Figure 4. Positions of overlapping or adjacent plasmid inserts in regions of difference (RDs) 4, 5, and 8. Identical results retrieved by different plasmids with overlapping sequences or sequences in closest proximity demonstrate the reproducibility and reliability of the differential genomic hybridization method.

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