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Volume 13, Number 7—July 2007

Synopsis

Thottapalayam Virus, a Prototype Shrewborne Hantavirus

Jin-Won Song*, Luck Ju Baek*, Connie S. Schmaljohn†, and Richard Yanagihara‡Comments to Author 
Author affiliations: *Korea University College of Medicine, Seoul, South Korea; †US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA; ‡University of Hawaii at Manoa, Honolulu, Hawaii, USA;

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Table 1

Susceptibility of small laboratory animals of various ages to fatal Thottapalayam virus meningoencephalitis*

Host species Age at injection, d Illness onset, d Mortality
rate, %
Mus musculus 1 7 100
5 7 100
10 6 88
14 6 94
21 8 67
Meriones unguiculatus 1 9 100
5 11 100
11 7 80
16 14 100
Peromyscus maniculatus 4 11 100
Monodelphis domestica 30 0

*Animals of various ages were injected intracerebrally with 6,000 PFU of Thottapalayam virus strain VRC-66412 and examined daily for neurologic signs and death.

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